Evidence map›Paper›PMID 36561957›Full record

ReviewToxicology reports2022

Health effects and known pathology associated with the use of E-cigarettes.

Maria Esteban-Lopez, Marissa D Perry, Luis D Garbinski, Marko Manevski, Mickensone Andre, Yasemin Ceyhan, Allen Caobi, Patience Paul, Lee Seng Lau, Julian Ramelow and 4 more

Open access · goldAbstract readReview
In one paragraph

Review in Toxicology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Comparison of Acute Effects of E-cigarettes With and Without Nicotine and Tobacco Cigarettes on Hemodynamic and Endothelial Parameters: A Systematic Review and Meta-analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Pooled it
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  5. Human Primary Mesenchymal Stem Cells Fail to Recover Full Osteogenic Differentiation Potential Following Washout of Electronic Cigarette Aerosol Extracts.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Maria Esteban-LopezDepartments of Human and Molecular Genetics, Florida International University, Miami, FL 33199, USA.
Marissa D PerryImmunology and Nano-medicine, Florida International University, Miami, FL 33199, USA.
Luis D GarbinskiCell Biology and Pharmacology and Florida International University, Miami, FL 33199, USA.
Marko ManevskiImmunology and Nano-medicine, Florida International University, Miami, FL 33199, USA.
Mickensone AndreImmunology and Nano-medicine, Florida International University, Miami, FL 33199, USA.
Yasemin CeyhanDepartments of Human and Molecular Genetics, Florida International University, Miami, FL 33199, USA.
Allen CaobiImmunology and Nano-medicine, Florida International University, Miami, FL 33199, USA.
Patience PaulTranslational Glycobiology, Florida International University, Miami, FL 33199, USA.
Lee Seng LauTranslational Glycobiology, Florida International University, Miami, FL 33199, USA.
Julian RamelowHerbert Wertheim College of Medicine, Biological Sciences in the College of Arts, Science and Education and the Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA.
Florida OwensImmunology and Nano-medicine, Florida International University, Miami, FL 33199, USA.
Joseph SouchakTranslational Glycobiology, Florida International University, Miami, FL 33199, USA.
Evan AlesTranslational Glycobiology, Florida International University, Miami, FL 33199, USA.
Nazira El-HageImmunology and Nano-medicine, Florida International University, Miami, FL 33199, USA.
Florida International University · US

Funding

Transdisciplinary Training in Biomolecular and Biomedical SciencesT32GM132054 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI DEGENNARO, MATTHEW, TSE-DINH, YUK-CHING · 2019 to 2023
$1.6M
NIGMS NIH HHS T32 GM132054
6 · The paper itself

Abstract

In recent years, new nicotine delivery methods have emerged, and many users are choosing electronic cigarettes (e-cigarettes) over traditional tobacco cigarettes. E-cigarette use is very popular among adolescents, with more than 3.5 million currently using these products in the US. Despite the increased prevalence of e-cigarette use, there is limited knowledge regarding the health impact of e-cigarettes on the general population. Based on published findings by others, E-cigarette is associated with lung injury outbreak, which increased health and safety concerns related to consuming this product. Different components of e-cigarettes, including food-safe liquid solvents and flavorings, can cause health issues related to pneumonia, pulmonary injury, and bronchiolitis. In addition, e-cigarettes contain alarmingly high levels of carcinogens and toxicants that may have long-lasting effects on other organ systems, including the development of neurological manifestations, lung cancer, cardiovascular disorders, and tooth decay. Despite the well- documented potential for harm, e-cigarettes do not appear to increase susceptibility to SARS-CoV- 2 infection. Furthermore, some studies have found that e-cigarette users experience improvements in lung health and minimal adverse effects. Therefore, more studies are needed to provide a definitive conclusion on the long-term safety of e-cigarettes. The purpose of this review is to inform the readers about the possible health-risks associated with the use of e-cigarettes, especially among the group of young and young-adults, from a molecular biology point of view.

Indexed as

AEC, airway epithelial cellsAM, alveolar macrophagesBAL, bronchial alveolar lavageCC16, Clara cell protein 16CM, cardiomyocyteCNS, central nervous systemCOPD, chronic obstructive pulmonary diseaseCSC, Cancer Stem CellCS, cigarette smokeCYP, cytochrome P450E2F1, E2F transcription factor 1E-cigarettese-cigarettes, electronic cigarettese-liquid, e-cigarette liquidEMT, epithelial-to-mesenchymal transitionENDS, electronic nicotine delivery systemEVALIEVALI, e-cigarette or vaping product use-associated lung injurye-vapor, e-cigarette vaporFDA, Food and Drug AdministrationFOXO3, forkhead box O3Health risksHNSCC, head and neck squamous cancer cellsHUVEC, human umbilical vein endothelial cellsIL, interleukiniPSC-EC, induced pluripotent stem cell-derived endothelial cellsLDL, low-density lipoproteinMCP-1, monocyte chemoattractant protein-1MMP9, matrix metallopeptidase 9MPP, Mycoplasma pneumoniae pneumoniaNET, neutrophil extracellular trapsNicotineNK, natural killerNOX, NADPH oxidaseNQO-1, NAD(P)H quinone dehydrogenase 1Nrf2, nuclear factor erythroid 2-related factor 2Oct4,, Octamer-binding transcription factor 4OGG1/2, 8-oxoguanine glycosylaseOS, oxidative stressPAFR, platelet-activating factor receptorPAHs, polycyclic aromatic hydrocarbonspAMPK, phospho-AMP-activated protein kinasePG, propylene glycolROS, reactive oxygen speciesSox2,, SRY (sex determining region Y)-box 2THC, TetrahydrocannabinolTNF‐α, tumor necrosis factor alphaVapingVAPI, vaping-associated pulmonary injuryVG, vegetable glycerinXPC, xeroderma pigmentosum complementation group CYap1, Yes associated protein 1ZEB, zinc finger E-box binding homeoboxZO-1, zonula occludens-1

Identifiers

PMID36561957
PMCPMC9764206
OpenAlexW4283008590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.