Evidence map›Paper›PMID 36561929›Full record

ArticleCancer research communications2022

IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis.

Anthony DiNatale, Asurayya Worrede, Waleed Iqbal, Michael Marchioli, Allison Toth, Martin Sjöström, Xiaolin Zhu, Eva Corey, Felix Y Feng, Wanding Zhou and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Anthony DiNataleDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA.
Asurayya WorredeDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA.
Waleed IqbalDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Michael MarchioliDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA.
Allison TothDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA.
Martin SjöströmDepartment of Radiation Oncology, UCSF, San Francisco, CA.
Xiaolin ZhuDepartment of Radiation Oncology, UCSF, San Francisco, CA.
Eva CoreyDepartment of Urology, University of Washington, WA.
Felix Y FengDepartment of Radiation Oncology, UCSF, San Francisco, CA.
Wanding ZhouDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Alessandro FatatisDepartment of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA.
University of California, San Francisco · USDrexel University · USUniversity of Pennsylvania · USMaryland State Department of Education · USSpringhouse · USThomas Jefferson University · USUniversity of Washington · US

Funding

X-Ray Crystallography and Macromolecular CharacterizationP30CA056036 · NCI · THOMAS JEFFERSON UNIVERSITY · PI Andrew Chapman · 1995 to 2026
$94.8M
TRANSCRIPTOME AND PROTEOME STRATIFICATION OF PROSTATE ADENOCARCINOMA PHENOTYPESP50CA097186 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETER S NELSON · 2002 to 2026
$58.1M
Steroid Metabolism in Castration-Resistant Prostate CancerP01CA163227 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PETER S NELSON · 2013 to 2026
$25.0M
NCI NIH HHS P01 CA163227NCI NIH HHS P30 CA056036NCI NIH HHS P50 CA097186
6 · The paper itself

Abstract

We report the inverse association between the expression of androgen receptor (AR) and interleukin-1beta (IL-1β) in a cohort of patients with metastatic castration resistant prostate cancer (mCRPC). We also discovered that AR represses the IL-1β gene by binding an androgen response element (ARE) half-site located within the promoter, which explains the IL-1β expression in AR-negative (AR

Indexed as

Bone NeoplasmsProstatic NeoplasmsAndrogensAnimalsHumansInterleukin-1betaMaleMiceReceptors, AndrogenSignal TransductionTumor MicroenvironmentAndrogensInterleukin-1betaReceptors, AndrogenAndrogen ReceptorIL-1βMetastasisMethylationProstate Cancer

Identifiers

PMID36561929
PMCPMC9770512
OpenAlexW4308710249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.