Evidence map›Paper›PMID 36561772›Full record

ReviewFrontiers in cardiovascular medicine2022

Arterial dissections: Common features and new perspectives.

Monique Bax, Valentin Romanov, Keerat Junday, Eleni Giannoulatou, Boris Martinac, Jason C Kovacic, Renjing Liu, Siiri E Iismaa, Robert M Graham

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  7. Spontaneous Coronary Artery Dissection in Women.Reviews in cardiovascular medicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Monique BaxVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Valentin RomanovVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Keerat JundayVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Eleni GiannoulatouVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Boris MartinacVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Jason C KovacicVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Renjing LiuVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Siiri E IismaaVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
Robert M GrahamVictor Chang Cardiac Research Institute, Darlinghurst, NSW, Australia.
UNSW Sydney · AUVictor Chang Cardiac Research Institute · AU

Funding

Therapeutic Mechanisms of Cardiac Progenitors in Ischemic CardiomyopathyR01HL135093 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FISH, KENNETH MICHAEL, KOVACIC, JASON CIRIL · 2017 to 2020
$3.4M
Understanding the Molecular Mechanisms of Fibromuscular DysplasiaR01HL148167 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KADIAN-DODOV, DANIELLA, KOVACIC, JASON CIRIL · 2020 to 2023
$2.8M
Toward Therapeutic Manipulation of Endothelial to Mesenchymal TransitionR01HL130423 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ISHIKAWA, KIYOTAKE, KOVACIC, JASON CIRIL · 2016 to 2020
$2.1M
NHLBI NIH HHS R01 HL130423NHLBI NIH HHS R01 HL135093NHLBI NIH HHS R01 HL148167
6 · The paper itself

Abstract

Arterial dissections, which involve an abrupt tear in the wall of a major artery resulting in the intramural accumulation of blood, are a family of catastrophic disorders causing major, potentially fatal sequelae. Involving diverse vascular beds, including the aorta or coronary, cervical, pulmonary, and visceral arteries, each type of dissection is devastating in its own way. Traditionally they have been studied in isolation, rather than collectively, owing largely to the distinct clinical consequences of dissections in different anatomical locations - such as stroke, myocardial infarction, and renal failure. Here, we review the shared and unique features of these arteriopathies to provide a better understanding of this family of disorders. Arterial dissections occur commonly in the young to middle-aged, and often in conjunction with hypertension and/or migraine; the latter suggesting they are part of a generalized vasculopathy. Genetic studies as well as cellular and molecular investigations of arterial dissections reveal striking similarities between dissection types, particularly their pathophysiology, which includes the presence or absence of an intimal tear and vasa vasorum dysfunction as a cause of intramural hemorrhage. Pathway perturbations common to all types of dissections include disruption of TGF-β signaling, the extracellular matrix, the cytoskeleton or metabolism, as evidenced by the finding of mutations in critical genes regulating these processes, including

Indexed as

aortic dissectionarterial dissectioncervical artery dissection (CeAD)endothelial cells (ECs)extracellular matrixspontaneous coronary artery dissection (SCAD)TGF-βvascular smooth muscle cells (VMSCs)

Identifiers

PMID36561772
PMCPMC9763901
OpenAlexW4311633715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.