Evidence map›Paper›PMID 36561765›Full record

ArticleCurrent analytical chemistry2022

Analysis of Stable Chelate-free Gadolinium Loaded Titanium Dioxide Nanoparticles for MRI-Guided Radionuclide Stimulated Cancer Treatment.

Lei Fang, Hengbo Huang, James D Quirk, Jie Zheng, Duanwen Shen, Brad Manion, Matthew Mixdorf, Partha Karmakar, Gail P Sudlow, Rui Tang and 1 more

Open access · greenAbstract read
In one paragraph

Article in Current analytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Self-illuminating liposome-derivedActa pharmaceutica Sinica. B · 2025
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lei FangSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Hengbo HuangSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
James D QuirkSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Jie ZhengSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Duanwen ShenSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Brad ManionSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Matthew MixdorfSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Partha KarmakarSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Gail P SudlowSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Rui TangSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Samuel AchilefuSchool of Medicine, Mallinckrodt Institute of Radiology, Washington University in St. Louis, Saint Louis, United States.
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI DIPERSIO, JOHN F. · 2015 to 2019
$11.5M
Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Alfred Hyoungju Kim · 2018 to 2026
$7.6M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPYR01CA260855 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2021 to 2025
$3.5M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY OF TUMORSR01EB021048 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2020
$2.3M
Imaging Goggles for Fluorescence-Guided SurgeryR01EB030987 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL, BURAS, WILLIAM ROBINSON · 2021 to 2024
$2.1M
Inhibition of NF-kB with siRNA/Peptide Nanoparticles for Arthritis TreatmentR01AR067491 · NIAMS · WASHINGTON UNIVERSITY · PI PHAM, CHRISTINE T., WICKLINE, SAMUEL A · 2015 to 2019
$1.8M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
FLUORESCENCE MOLECULAR TOMOGRAPHY SYSTEMS10OD020129 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2015
$330k
FLUORESCENCE LIFETIME IMAGING MICROSCOPY SYSTEMS10OD016237 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2014 to 2014
$267k
IVIS LUMINA II XR FOR OPTICAL IMAGING OF RADIOPHARMACEUTICALSS10RR031625 · NCRR · WASHINGTON UNIVERSITY · PI TAI, YUAN-CHUAN · 2011 to 2011
$218k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA260855NCI NIH HHS U54 CA199092NCRR NIH HHS S10 RR031625NIAMS NIH HHS P30 AR073752NIAMS NIH HHS R01 AR067491NIBIB NIH HHS R01 EB021048NIBIB NIH HHS R01 EB030987NIH HHS S10 OD016237NIH HHS S10 OD020129NIH HHS S10 OD027042
6 · The paper itself

Abstract

Background: Recent studies demonstrate that titanium dioxide nanoparticles (TiO Objective: Given the use of gadolinium (Gd) chelates as effective contrast agents for magnetic resonance imaging (MRI), this study aims to (1) develop hybrid TiO Methods: A chelate-free, heat-induced method was used to load Gd onto TiO Results: A simple colorimetric assay accurately determined both the loading and stability of the NPs compared with the expensive and complex ICP-MS method. Coating of the TiO Conclusion: This work demonstrates that Arsenazo III colorimetric assay can substitute ICP-MS for determining the loading and stability of Gd-doped TiO

Indexed as

cancercerenkov radiationcolorimetric assaymagnetic resonance imagingMRIreactive oxygen speciesrelaxivityTitanium dioxide

Identifiers

PMID36561765
PMCPMC9770661
OpenAlexW4221071647

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.