Evidence map›Paper›PMID 36561749›Full record

ArticleFrontiers in immunology2022

A therapeutic vaccine strategy to prevent

Whitney Rabacal, Finja Schweitzer, Heather M Kling, Lizabeth Buzzelli, Emily Rayens, Karen A Norris

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Whitney RabacalCenter for Vaccines and Immunology, Department of Infectious Diseases, University of Georgia, Athens, GA, United States.
Finja SchweitzerCenter for Vaccines and Immunology, Department of Infectious Diseases, University of Georgia, Athens, GA, United States.
Heather M KlingDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, United States.
Lizabeth BuzzelliCenter for Vaccines and Immunology, Department of Infectious Diseases, University of Georgia, Athens, GA, United States.
Emily RayensCenter for Vaccines and Immunology, Department of Infectious Diseases, University of Georgia, Athens, GA, United States.
Karen A NorrisCenter for Vaccines and Immunology, Department of Infectious Diseases, University of Georgia, Athens, GA, United States.
University of Georgia · USUniversity of Pittsburgh · US

Funding

cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0M
Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1M
Prevention and Treatment of Pneumocystis PneumoniaR01AI148365 · NIAID · UNIVERSITY OF GEORGIA · PI NORRIS, KAREN A · 2020 to 2024
$3.7M
NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS R01 AI148365NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
6 · The paper itself

Abstract

Introduction: Methods: In the present study, we used the SIV model of HIV infection to address whether therapeutic vaccination with the iNKT cell-activating adjuvant α-galactosylceramide (α-GC) and KEX1 (α-GC+KEX1) can effectively boost anti- Results: Immunization of antigen-experienced NHPs with α-GC+KEX1 during the early chronic phase of SIV-infection significantly boosted anti- Conclusion: These studies present a novel strategy for stimulating durable anti-

Indexed as

CoinfectionHIV InfectionsPneumocystisPneumonia, PneumocystisSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAdjuvants, ImmunologicAnimalsImmunocompromised HostMacacaPrimatesVaccines, SyntheticAdjuvants, ImmunologicVaccines, Syntheticand non-human primate (NHP)fungal vaccineHIV/SIVimmunocompromisedPneumocystisPneumocystis pneumonia (PCP/PJP)α-galactosylceramide (α-GC, α-GalCer, KRN7000)

Identifiers

PMID36561749
PMCPMC9763597
OpenAlexW4311705982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.