Evidence map›Paper›PMID 36561720›Full record

ArticleFrontiers in medicine2022

Clinical and biochemical characteristics of people experiencing post-coronavirus disease 2019-related symptoms: A prospective follow-up investigation.

Assim A Alfadda, Mohamed Rafiullah, Mohammad Alkhowaiter, Naif Alotaibi, Musa Alzahrani, Khalifa Binkhamis, Khalid Siddiqui, Amira Youssef, Haifa Altalhi, Ibrahim Almaghlouth and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Endotheliopathy in Acute COVID-19 and Long COVID.International journal of molecular sciences · 2023
    Pooled it
  4. Article
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  9. B Cell Dynamics and Transitional B Cells in Long COVID.Current issues in molecular biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Assim A AlfaddaStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohamed RafiullahStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Mohammad AlkhowaiterDepartment of Internal Medicine, College of Medicine, King Khalid University Hospital, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Naif AlotaibiDepartment of Medicine, College of Medicine, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Musa AlzahraniDepartment of Internal Medicine, College of Medicine, King Khalid University Hospital, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Khalifa BinkhamisDepartment of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Khalid SiddiquiStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Amira YoussefStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Haifa AltalhiInfection Control Department, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Ibrahim AlmaghlouthRheumatology Department, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Mohammed AlarifiIntensive Care Department, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Saleh AlbanyanDepartment of Internal Medicine, College of Medicine, King Khalid University Hospital, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
Mohammed F AlosaimiDepartment of Pediatrics, King Khalid University Hospital, King Saud University Medical City, Riyadh, Saudi Arabia.
Arthur IsnaniObesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Shaik Sarfaraz NawazStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Khalid AlayedDepartment of Internal Medicine, College of Medicine, King Khalid University Hospital, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
King Saud University · SAKing Khalid University Hospital · SAKing Saud Medical City · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Post-acute coronavirus disease 2019 (COVID-19) syndrome, also known as long COVID, is a prolonged illness after the acute phase of COVID-19. Hospitalized patients were known to have persisting symptoms of fatigue, headache, dyspnea, and anosmia. There is a need to describe the characteristics of individuals with post-COVID-19 symptoms in comparison to the baseline characteristics. Purpose: To investigate the clinical and biochemical characteristics of people who recovered from COVID-19 after 6 months of discharge from the hospital. Methods: This was a prospective follow-up investigation of hospitalized and discharged COVID-19 patients. Adult patients admitted to King Saud University Medical City, Riyadh, Saudi Arabia, with laboratory-confirmed COVID-19 and discharged were recruited. The baseline demographic information, comorbidities, vital signs and symptoms, laboratory parameters, COVID-19 therapy, and outcomes were collected from the medical records. Blood samples were collected for cytokines estimation. A detailed interview about signs and symptoms was undertaken during the follow-up. Results: Half of the followed-up people reported experiencing at least one of the COVID-19-related symptoms. The mean blood pressure was found higher in follow-up. People with the symptoms were characterized by low lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without any post-COVID-19 symptoms. Cytokines IL-8, VEGF, and MCP-1 were higher in people with the most frequent symptoms. Conclusion: People with post-COVID-19 symptoms were characterized by lower lymphocyte count, lower serum calcium levels, and hyperglycemia compared to people without symptoms. Individuals with the most frequent post-COVID-19 symptoms had higher baseline pro-inflammatory, chemotactic, and angiogenic cytokines.

Indexed as

COVID-19long COVIDPASCpost-COVID-19SARS-CoV-2

Identifiers

PMID36561720
PMCPMC9763306
OpenAlexW4311619486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.