Evidence map›Paper›PMID 36561337›Full record

ArticleFrontiers in pharmacology2022

Discovery of pyrrole derivatives as acetylcholinesterase-sparing butyrylcholinesterase inhibitor.

Shouyuan Sun, Tao Shi, Yan Peng, Honghua Zhang, Linsheng Zhuo, Xue Peng, Qien Li, Manxia Wang, Shuzhi Wang, Zhen Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shouyuan SunLanzhou University Second Hospital, Lanzhou, China.
Tao ShiSchool of Pharmacy, Lanzhou University, Lanzhou, China.
Yan PengSchool of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, China.
Honghua ZhangSchool of Pharmacy, Lanzhou University, Lanzhou, China.
Linsheng ZhuoSchool of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, China.
Xue PengSchool of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, China.
Qien LiTibetan Medical College, Qinghai University, Xining, China.
Manxia WangLanzhou University Second Hospital, Lanzhou, China.
Shuzhi WangSchool of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, China.
Zhen WangSchool of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, China.
University of South China · CNLanzhou University · CNLanzhou University Second Hospital · CNQinghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inspired by the crucial roles of (hetero)aryl rings in cholinesterase inhibitors and the pyrrole ring in new drug discovery, we synthesized 19 pyrrole derivatives and investigated their cholinesterase inhibitory activity. As a result, compounds 3o, 3p, and 3s with a 1,3-diaryl-pyrrole skeleton showed high selectivity toward BChE over AChE with a best IC

Indexed as

acetylcholinesterasebutyrylcholinesteraseenzyme kineticmolecular dockingsubstituted pyrroles

Identifiers

PMID36561337
PMCPMC9763612
OpenAlexW4311630972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.