Evidence map›Paper›PMID 36561184›Full record

ArticlebioRxiv : the preprint server for biology2023

Chaotic signatures in host-microbe interactions.

Yehonatan Sella, Nichole A Broderick, Kaitlin Stouffer, Deborah L McEwan, Frederick M Ausubel, Arturo Casadevall, Aviv Bergman

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yehonatan SellaDepartment of Systems and Computational Biology, Albert Einstein College of Medicine,1301 Morris Park Ave, Bronx, NY 10461, USA.ORCID 0000-0002-2667-5888
Nichole A BroderickDepartment of Biology, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-6830-9456
Kaitlin StoufferDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD.ORCID 0000-0003-4547-8836
Deborah L McEwanDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Frederick M AusubelDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0002-6927-8460
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, MD.ORCID 0000-0002-9402-9167
Aviv BergmanDepartment of Systems and Computational Biology, Albert Einstein College of Medicine,1301 Morris Park Ave, Bronx, NY 10461, USA.ORCID 0000-0002-6340-2125
Johns Hopkins University · USAlbert Einstein College of Medicine · USMassachusetts General Hospital · US

Funding

Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
Conjugate vaccines for prevention and treatment of cryptococcosis - COVID-19 Revision SupplementR01AI152078 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2020 to 2024
$5.1M
In Vivo Multiphoton Based Imaging of Complex Cancer Cell BehaviorR01CA164468 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERKHUSHA, VLADISLAV · 2011 to 2015
$3.8M
Systems biology analysis of in vivo impact of substance abuse on HIV infectionR01DA033788 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GOLDSTEIN, HARRIS · 2012 to 2016
$3.0M
Non-genetic inheritance: mechanisms of microbiome-mediated transgenerational changeR35GM128871 · NIGMS · UNIVERSITY OF CONNECTICUT STORRS · PI BRODERICK, NICHOLE A · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA164468NHLBI NIH HHS R01 HL059842NIAID NIH HHS R01 AI052733NIAID NIH HHS R01 AI152078NIDA NIH HHS R01 DA033788NIGMS NIH HHS R35 GM128871
6 · The paper itself

Abstract

Host-microbe interactions constitute dynamical systems that can be represented by mathematical formulations that determine their dynamic nature, and are categorized as deterministic, stochastic, or chaotic. Knowing the type of dynamical interaction is essential for understanding the system under study. Very little experimental work has been done to determine the dynamical characteristics of host-microbe interactions and its study poses significant challenges. The most straightforward experimental outcome involves an observation of time to death upon infection. However, in measuring this outcome, the internal parameters, and the dynamics of each particular host-microbe interaction in a population of interactions are hidden from the experimentalist. To investigate whether a time-to-death (time to event) dataset provides adequate information for searching for chaotic signatures, we first determined our ability to detect chaos in simulated data sets of time-to-event measurements and successfully distinguished the time-to-event distribution of a chaotic process from a comparable stochastic one. To do so, we introduced an

Identifiers

PMID36561184
PMCPMC9774220
OpenAlexW4312219320

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.