ArticleJHEP reports : innovation in hepatology2023
Low HDL-cholesterol levels predict hepatocellular carcinoma development in individuals with liver fibrosis.
Article in JHEP reports : innovation in hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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55 citing papers in PubMed, 66 citations in OpenAlex.
- Association of platelet to highdensity lipoprotein cholesterol ratio (PHR) with stroke and its subtypes: a large prospective cohort study.Scientific reports · 2026Article
- The preoperative LDL-C to HDL-C ratio evaluates prognosis in hepatocellular carcinoma patients after hepatectomy.Discover oncology · 2026Article
- Platelet-to-high-density lipoprotein ratio predicts postoperative overall survival in hepatocellular carcinoma: a retrospective cohort study.World journal of surgical oncology · 2026Article
- [Prediction of the occurrence risk of progressive liver fibrosis in patients with metabolic-associated fatty liver disease based on the SMOTE algorithm and nomogram].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Article
- Review
- Comparison of the predictive power of novel insulin resistance, lipid metabolism and obesity indices for the risk of developing dyslipidaemia in adults.BMC endocrine disorders · 2026Article
- Development and validation of a logistic regression-based nomogram for predicting 1-year all-cause death and heart failure rehospitalization in hypertensive patients with chronic heart failure.Frontiers in cardiovascular medicine · 2026Article
- Systemic immuno-metabolic inflammatory indices (neutrophil-to-HDL cholesterol ratio and systemic inflammation response index) are strongly associated with metabolic dysfunction-associated steatotic liver disease: a propensity score-matched study.Frontiers in immunology · 2026Article
- Association Between Serum Lipid-Bilirubin Ratio and Clinical Prognosis Among Patients Undergoing Percutaneous Coronary Intervention After Coronary Artery Bypass Grafting.Reviews in cardiovascular medicine · 2025Article
- Association between high-density lipoprotein cholesterol-related inflammatory markers and female infertility: a cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES 2013-2018).BMC women's health · 2025Article
- Association between glycated hemoglobin/high-density lipoprotein ratio and nonalcoholic fatty liver disease in a U.S. nondiabetic population: a cross-sectional study based on NHANES 2017-2020 data.BMC gastroenterology · 2025Article
- Role of Liquid Biopsy for Early Detection, Prognosis, and Therapeutic Monitoring of Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland) · 2025Review
- Is UA/HDL-C a Reliable Surrogate Marker for Fatty Liver? A Comparative Evaluation with Metabolic Scores in a Mexican Population: The Genetics of Atherosclerotic Disease Study.Diagnostics (Basel, Switzerland) · 2025Article
- Association between platelet-to-high-density lipoprotein cholesterol ratio and gallstone prevalence in the American adult population: a cross-sectional study analysis.BMC gastroenterology · 2025Article
- Understanding the role of Hedgehog signaling pathway and gut dysbiosis in fueling liver cancer.Molecular biology reports · 2025Review
- Host-Microbiota-Parasite Interactions in Grass Carp: Insights fromMicroorganisms · 2025Article
- Machine learning-based models for advanced fibrosis in non-alcoholic steatohepatitis patients: A cohort study.World journal of gastroenterology · 2025Article
- The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hepatic steatosis and liver fibrosis among US adults based on NHANES.Scientific reports · 2025Article
- Association between high-density lipoprotein cholesterol and 7-autoantibodies: a study on physical examination data from 2018 to 2023.Frontiers in endocrinology · 2025Article
- The uric acid-to-HDL ratio as a predictive biomarker for depression risk in adult women.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Aims: Dysmetabolic conditions could drive liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD), increasing susceptibility to hepatocellular carcinoma (HCC). We therefore aimed to identify novel predictive biomarkers of HCC in patients with and without liver fibrosis. Methods: A total of 1,234 patients with putative metabolic conditions and NAFLD were consecutively assessed in our outpatient clinic. Clinical and biochemical data were recorded, and then liver ultrasonography was performed annually for 5 years to detect HCC onset. For the analysis, the population was first divided according to HCC diagnosis; then a further subdivision of those who did not develop HCC was performed based on the presence or absence of liver fibrosis at time 0. Results: Sixteen HCC cases were recorded in 5 years. None of our patients had been diagnosed with cirrhosis before HCC was detected. Compared to patients who did not develop HCC, those who did had higher liver transaminases and fibrosis scores at time 0 ( Conclusions: This study identifies HDL-c as a Impact and implications: Visceral adiposity and its associated conditions, such as chronic inflammation and insulin resistance, may play a pivotal role in hepatocellular carcinoma development in patients with non-alcoholic fatty liver disease. We provide new insights on the underlying mechanisms of its pathogenesis, shedding light on the involvement of low levels of "good" HDL-cholesterol. We recommend integrating dietary regimens and advice on healthy lifestyles into the clinical management of non-alcoholic fatty liver disease, with the goal of reducing the incidence of hepatocellular carcinoma.
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