Evidence map›Paper›PMID 36561048›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Modeling cartilage pathology in mucopolysaccharidosis VI using iPSCs reveals early dysregulation of chondrogenic and metabolic gene expression.

M Broeders, Jgj van Rooij, E Oussoren, Tjm van Gestel, Ca Smith, Sj Kimber, Rm Verdijk, Maem Wagenmakers, Jmp van den Hout, At van der Ploeg and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

M BroedersDepartment of Pediatrics, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Jgj van RooijDepartment of Internal Medicine, Erasmus MC Medical Center, Rotterdam, Netherlands.
E OussorenDepartment of Pediatrics, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Tjm van GestelDepartment of Pediatrics, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Ca SmithDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom.
Sj KimberDivision of Cell Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom.
Rm VerdijkDepartment of Pathology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Maem WagenmakersCenter for Lysosomal and Metabolic Diseases, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Jmp van den HoutDepartment of Pediatrics, Erasmus MC University Medical Center, Rotterdam, Netherlands.
At van der PloegDepartment of Pediatrics, Erasmus MC University Medical Center, Rotterdam, Netherlands.
R NarcisiDepartment of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Wwmp PijnappelDepartment of Pediatrics, Erasmus MC University Medical Center, Rotterdam, Netherlands.
Erasmus MC · NLHenry Royce Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucopolysaccharidosis type VI (MPS VI) is a metabolic disorder caused by disease-associated variants in the Arylsulfatase B (

Indexed as

cartilagedisease modelinginduced pluripotent stem cellslysosomal storage diseasemucopolysaccharidosis type VI

Identifiers

PMID36561048
PMCPMC9763729
OpenAlexW4311633824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.