Evidence map›Paper›PMID 36560782›Full record

ReviewViruses2022

COVID-19 Vaccination in Patients with Chronic Liver Disease.

Georgios Schinas, Eleni Polyzou, Fevronia Mitropetrou, Aristotelis Pazionis, Charalambos Gogos, Christos Triantos, Karolina Akinosoglou

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Vaccination Strategies for a Liver Transplant Recipient.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Georgios SchinasDepartment of Internal Medicine, University General Hospital of Patras, 26504 Rio, Greece.ORCID 0000-0001-7963-1865
Eleni PolyzouDepartment of Internal Medicine, University General Hospital of Patras, 26504 Rio, Greece.
Fevronia MitropetrouDepartment of Medicine, University of Patras, 26504 Rio, Greece.
Aristotelis PazionisDepartment of Medicine, University of Patras, 26504 Rio, Greece.
Charalambos GogosDepartment of Internal Medicine, University General Hospital of Patras, 26504 Rio, Greece.
Christos TriantosDepartment of Medicine, University of Patras, 26504 Rio, Greece.ORCID 0000-0003-3094-8209
Karolina AkinosoglouDepartment of Internal Medicine, University General Hospital of Patras, 26504 Rio, Greece.ORCID 0000-0002-4289-9494
University of Patras · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination against SARS-CoV-2 has become a central public health issue, primarily for vulnerable populations such as individuals with Chronic Liver Disease (CLD). Increased COVID-19-related mortality and disease severity has been noted in this subgroup of patients. Severe COVID-19 tends to further deregulate liver function in patients with chronic liver failure or cirrhosis and even reactivate hepatitis in people living with HBV or HCV. In addition, impaired hepatic function leads to several limitations in possible therapeutic interventions. Chronic hepatic dysregulation, along with the underlying cirrhosis-associated immune dysfunction (CAID), leads to a decreased immune response to vaccination that, in turn, may result in reduced efficacy rates and lowered lasting protection. According to current guidelines, timely vaccination and frequent booster shot administration are deemed necessary in this context. Vaccination-related adverse events are mostly mild in nature and similar to those reported in the general population, whereas the incidence of liver injury following vaccination is relatively rare. We aimed to review available evidence and recommendations associated with COVID-19 vaccination in patients with chronic liver disease, and provide insight to current issues and future directions.

Indexed as

COVID-19COVID-19 VaccinesLiver DiseasesHumansLiver CirrhosisSARS-CoV-2VaccinationCOVID-19 Vaccineschronic liver diseaseCOVID-19 vaccinesimmunizationmRNA vaccineSARS-CoV-2

Identifiers

PMID36560782
PMCPMC9785164
OpenAlexW4311357638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.