Evidence map›Paper›PMID 36560778›Full record

ArticleViruses2022

The Persistence of HIV Diversity, Transcription, and Nef Protein in Kaposi's Sarcoma Tumors during Antiretroviral Therapy.

David J Nolan, Rebecca Rose, Rongzhen Zhang, Alan Leong, Gary B Fogel, Larissa L S Scholte, Jeffrey M Bethony, Paige Bracci, Susanna L Lamers, Michael S McGrath

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

David J NolanBioinfoexperts, LLC, Thibodaux, LA 70301, USA.ORCID 0000-0002-9114-7002
Rebecca RoseBioinfoexperts, LLC, Thibodaux, LA 70301, USA.
Rongzhen ZhangDepartments of Laboratory Medicine, Pathology and Medicine, The University of California at San Francisco, San Francisco, CA 94110, USA.
Alan LeongDepartments of Laboratory Medicine, Pathology and Medicine, The University of California at San Francisco, San Francisco, CA 94110, USA.
Gary B FogelNatural Selection, Inc., San Diego, CA 92127, USA.
Larissa L S ScholteDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA.
Jeffrey M BethonyDepartment of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC 20037, USA.
Paige BracciThe AIDS and Cancer Specimen Resource, San Francisco, CA 94110, USA.
Susanna L LamersBioinfoexperts, LLC, Thibodaux, LA 70301, USA.
Michael S McGrathDepartments of Laboratory Medicine, Pathology and Medicine, The University of California at San Francisco, San Francisco, CA 94110, USA.ORCID 0000-0002-7232-2602
University of California, San Francisco · USGeorge Washington University · USNatural Selection (United States) · US

Funding

AIDS and Cancer Specimen Resource (ACSR)UM1CA181255 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeffrey Michael Bethony, Anna Coghill · 2013 to 2026
$56.7M
Pathogenesis of the cART unresponsive Kaposi’s sarcoma tumor nicheR01CA239263 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCGRATH, MICHAEL SHANNON · 2019 to 2023
$2.8M
NCI NIH HHS R01 CA239263NCI NIH HHS UM1 CA181255
6 · The paper itself

Abstract

Epidemic Kaposi's sarcoma (KS), defined by co-infection with Human Herpes Virus 8 (HHV-8) and the Human Immunodeficiency Virus (HIV), is a major cause of mortality in sub-Saharan Africa. Antiretroviral therapy (ART) significantly reduces the risk of developing KS, and for those with KS, tumors frequently resolve with ART alone. However, for unknown reasons, a significant number of KS cases do not resolve and can progress to death. To explore how HIV responds to ART in the KS tumor microenvironment, we sequenced HIV

Indexed as

Herpesvirus 8, HumanHIV Infectionsnef Gene Products, Human Immunodeficiency VirusSarcoma, KaposiGene Products, nefHIVHumansLeukocytes, MononuclearRNATumor MicroenvironmentGene Products, nefnef Gene Products, Human Immunodeficiency VirusRNAHIV NefHIV transcriptionKaposi’s sarcomaviral reservoirs

Identifiers

PMID36560778
PMCPMC9782636
OpenAlexW4311376559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.