Evidence map›Paper›PMID 36560659›Full record

ArticleViruses2022

The Risk of Autoimmunity Development following mRNA COVID-19 Vaccination.

Jerzy Świerkot, Marta Madej, Magdalena Szmyrka, Lucyna Korman, Renata Sokolik, Iga Andrasiak, Ewa Morgiel, Agata Sebastian

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. The strategies and advances of mRNA translation booster.Asian journal of pharmaceutical sciences · 2025
    Review
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jerzy ŚwierkotDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-566 Wroclaw, Poland.
Marta MadejDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-566 Wroclaw, Poland.ORCID 0000-0002-4523-9272
Magdalena SzmyrkaDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-566 Wroclaw, Poland.
Lucyna KormanDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-566 Wroclaw, Poland.
Renata SokolikDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-566 Wroclaw, Poland.
Iga AndrasiakWroMedica Research Center, 50-566 Wroclaw, Poland.
Ewa MorgielDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-566 Wroclaw, Poland.ORCID 0000-0002-9506-698X
Agata SebastianDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-566 Wroclaw, Poland.ORCID 0000-0001-6332-8714
Wroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The broad spectrum of interactions between autoimmune diseases and the SARS-CoV-2 vaccination is not fully understood. This study aims to evaluate the prevalence of anti-nuclear antibodies (ANA), anti-ENA, anticardiolipin antibodies (ACL), and anti-beta-2 glycoprotein I antibodies (anti-β2GPI) before and after the SARS-CoV-2 mRNA vaccination in a real-life setting in healthcare professionals. The identification of risk factors associated with vaccine immunogenicity was evaluated. The study group consisted of employees of two hospitals (354 individuals). Samples for antibody assays were collected before vaccination and at 7-9 months after complete immunisation. There was no significant increase in the prevalence of ANA, ACL or anti-β2GPI antibodies, or autoimmune diseases in subjects who were vaccinated 7-9 months after complete immunisation. In terms of detected anti-ENA, the anti-DFS70 antibodies were found in 6 times more subjects than before vaccination at the second blood draw (in 18 and 3 subjects, respectively) (

Indexed as

Autoimmune DiseasesCOVID-19COVID-19 VaccinesAntibodies, ViralAutoantibodiesAutoimmunitybeta 2-Glycoprotein IHumansSARS-CoV-2VaccinationAntibodies, ViralAutoantibodiesbeta 2-Glycoprotein ICOVID-19 Vaccinesautoantibodiesautoimmune diseasesCOVID-19vaccination

Identifiers

PMID36560659
PMCPMC9788148
OpenAlexW4310213906

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.