Evidence map›Paper›PMID 36560606›Full record

ArticleViruses2022

Chitinase-3-like Protein 1 Is Associated with Poor Virologic Control and Immune Activation in Children Living with HIV.

Isabelle Bernard, Doris G Ransy, Jason Brophy, Fatima Kakkar, Ari Bitnun, Lindy Samson, Stanley Read, Hugo Soudeyns, Michael T Hawkes, Epic Study Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Isabelle BernardDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Doris G RansyUnité d'immunopathologie Virale, Centre de Recherche du CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.
Jason BrophyDivision of Infectious Diseases, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada.ORCID 0000-0001-9154-8060
Fatima KakkarDepartment of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, QC H3T 1C5, Canada.
Ari BitnunDivision of Infectious Diseases, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.
Lindy SamsonDivision of Infectious Diseases, Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada.
Stanley ReadDivision of Infectious Diseases, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada.
Hugo SoudeynsUnité d'immunopathologie Virale, Centre de Recherche du CHU Sainte-Justine, Montreal, QC H3T 1C5, Canada.ORCID 0000-0001-5857-3176
Michael T HawkesDepartment of Pediatrics, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0002-4122-0937
Epic Study Group
Centre Hospitalier Universitaire Sainte-Justine · CAUniversity of Alberta · CAUniversity of Toronto · CAChildren's Hospital of Eastern Ontario · CAUniversity of Ottawa · CA

Funding

CIHR HIG-133051
6 · The paper itself

Abstract

Perinatally infected children living with HIV (CLWH) face lifelong infection and associated inflammatory injury. Chitinase-like 3 protein-1 (CHI3L1) is expressed by activated neutrophils and may be a clinically informative marker of systemic inflammation in CLWH. We conducted a multi-centre, cross-sectional study of CLWH, enrolled in the Early Pediatric Initiation Canadian Child Cure Cohort Study (EPIC

Indexed as

Chitinase-3-Like Protein 1HIV InfectionsAdolescentAntiretroviral Therapy, Highly ActiveCanadaCD4 Lymphocyte CountChildCohort StudiesCross-Sectional StudiesFemaleHumansMaleViral LoadCHI3L1 protein, humanChitinase-3-Like Protein 1childchitinase-3-like protein 1HIVinflammationmicrobial translocationneutrophil

Identifiers

PMID36560606
PMCPMC9786985
OpenAlexW4309839637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.