Evidence map›Paper›PMID 36560603›Full record

ArticleViruses2022

Dynamics and Patterning of 5-Hydroxytryptamine 2 Subtype Receptors in JC Polyomavirus Entry.

Kashif Mehmood, Michael P Wilczek, Jeanne K DuShane, Matthew T Parent, Colleen L Mayberry, Jaqulin N Wallace, Francois L Levasseur, Tristan M Fong, Samuel T Hess, Melissa S Maginnis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kashif MehmoodDepartment of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, USA.
Michael P WilczekDepartment of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, USA.
Jeanne K DuShaneDepartment of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, USA.
Matthew T ParentDepartment of Physics & Astronomy, The University of Maine, Orono, ME 04469, USA.ORCID 0000-0002-3346-1271
Colleen L MayberryDepartment of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, USA.
Jaqulin N WallaceDepartment of Physics & Astronomy, The University of Maine, Orono, ME 04469, USA.ORCID 0000-0001-5150-9390
Francois L LevasseurDepartment of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, USA.
Tristan M FongDepartment of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, USA.
Samuel T HessDepartment of Physics & Astronomy, The University of Maine, Orono, ME 04469, USA.
Melissa S MaginnisDepartment of Molecular and Biomedical Sciences, The University of Maine, Orono, ME 04469, USA.
University of Maine · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Characterization of Viral Receptors and Signaling Networks in JC Polyomavirus InfectionR15AI144686 · NIAID · UNIVERSITY OF MAINE ORONO · PI MAGINNIS, MELISSA · 2019 to 2022
$876k
Mechanism of Interaction between Influenza Hemagglutinin and Host Cell PhosphoinositidesR15GM139070 · NIGMS · UNIVERSITY OF MAINE ORONO · PI HESS, SAMUEL T · 2020 to 2020
$428k
Mechanism of Association between Influenza Hemagglutinin and the Host Cell Actin CytoskeletonR15GM116002 · NIGMS · UNIVERSITY OF MAINE ORONO · PI HESS, SAMUEL T · 2015 to 2015
$337k
NIAID NIH HHS R15 AI144686NIGMS NIH HHS P20 GM103423NIGMS NIH HHS R15 GM116002NIGMS NIH HHS R15 GM139070
6 · The paper itself

Abstract

The organization and dynamics of plasma membrane receptors are a critical link in virus-receptor interactions, which finetune signaling efficiency and determine cellular responses during infection. Characterizing the mechanisms responsible for the active rearrangement and clustering of receptors may aid in developing novel strategies for the therapeutic treatment of viruses. Virus-receptor interactions are poorly understood at the nanoscale, yet they present an attractive target for the design of drugs and for the illumination of viral infection and pathogenesis. This study utilizes super-resolution microscopy and related techniques, which surpass traditional microscopy resolution limitations, to provide both a spatial and temporal assessment of the interactions of human JC polyomavirus (JCPyV) with 5-hydroxytrypamine 2 receptors (5-HT

Indexed as

JC VirusLeukoencephalopathy, Progressive MultifocalPolyomavirus InfectionsHumansSerotoninVirus AttachmentSerotonin5-HT2 receptorsFPALMJC polyomavirusreceptor clusteringsuper resolution microscopy

Identifiers

PMID36560603
PMCPMC9782046
OpenAlexW4309723373

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.