Evidence map›Paper›PMID 36560593›Full record

ArticleVaccines2022

Serological Responses up to 9 Months following COVID-19 mRNA Vaccination in Residents and Health-Care Workers of Long-Term Care Facilities: A Multicenter Prospective Cohort Study in Northern Italy.

Costanza Vicentini, Carla Maria Zotti, Alessandro Roberto Cornio, Jacopo Garlasco, Noemi Marengo, Davide Meddis, Savina Ditommaso, Monica Giacomuzzi, Gabriele Memoli, Valerio Bordino and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Costanza VicentiniDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.ORCID 0000-0002-0056-2463
Carla Maria ZottiDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.
Alessandro Roberto CornioDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.
Jacopo GarlascoDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.ORCID 0000-0001-6331-8276
Noemi MarengoDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.ORCID 0000-0003-2924-7923
Davide MeddisDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.
Savina DitommasoDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.ORCID 0000-0003-1590-9009
Monica GiacomuzziDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.ORCID 0000-0002-9722-6334
Gabriele MemoliDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.ORCID 0000-0002-7211-079X
Valerio BordinoDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.ORCID 0000-0002-1173-0469
Maria Michela GianinoDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.
On Behalf Of The Collaborating GroupDepartment of Public Health and Paediatrics, University of Turin, Via Santena 5bis, 10126 Torino, Italy.
University of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long-term care facilities (LTCFs) were severely affected by COVID-19, in particular in Northern Italy. We aimed to assess antibody responses among residents and healthcare workers (HCWs) of 13 LTCFs through serum samples collected at three time points: prior to, two weeks, and 9 months after receiving Pfizer/BNT162b2 SARS-CoV-2 mRNA vaccine (respectively t0, t1, and t2). IgG antibodies targeted towards the S1 domain of the spike protein were measured, and results were expressed in binding antibody units (BAU/mL). Friedman's average rank test was performed to compare antibody titres between the three time points. Two logistic regression models were built to identify independent predictors of (1) developing and (2) maintaining a significant antibody response to vaccination, using a previously identified threshold. In total, 534 subjects were enrolled (371 HCWs and 163 residents). The antibody titres at t1 were the highest; at t2, the IgG titres significantly decreased, remaining however 10 times higher compared to titres at t0. Previous infection was the only significant predictor of developing and maintaining a response over threshold in both models. Results of this study provided further insights on the humoral response elicited by vaccination, and on host factors determining variations in its magnitude and kinetics.

Indexed as

COVID-19ItalyLTCFs

Identifiers

PMID36560593
PMCPMC9784767
OpenAlexW4311885248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.