Evidence map›Paper›PMID 36560568›Full record

ArticleVaccines2022

A Vaccine Targeting Ovine Herpesvirus 2 Glycoprotein B Protects against Sheep-Associated Malignant Catarrhal Fever.

Cristina W Cunha, Katherine N Baker, Donal O'Toole, Emily Cole, Smriti Shringi, Benjamin G Dewals, Alain Vanderplasschen, Hong Li

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Cristina W CunhaAnimal Disease Research Unit, Agricultural Research Service, USDA, Pullman, WA 99164, USA.ORCID 0000-0002-8168-5448
Katherine N BakerAnimal Disease Research Unit, Agricultural Research Service, USDA, Pullman, WA 99164, USA.
Donal O'TooleDepartment of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA.ORCID 0000-0002-5174-8487
Emily ColeDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA.
Smriti ShringiDepartment of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0001-9212-9175
Benjamin G DewalsFundamental and Applied Research in Animals and Health (FARAH), Immunology-Vaccinology, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium.ORCID 0000-0003-1497-0799
Alain VanderplasschenFundamental and Applied Research in Animals and Health (FARAH), Immunology-Vaccinology, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium.
Hong LiAnimal Disease Research Unit, Agricultural Research Service, USDA, Pullman, WA 99164, USA.
Agricultural Research Service · USUniversity of Liège · BEWashington State University · USUniversity of Wyoming · US

Funding

United States Department of Agriculture USDA-ARS CWU 2090-32000-037-00D
6 · The paper itself

Abstract

Malignant catarrhal fever (MCF) is a complex and often fatal disease of ungulates. Effective vaccines are needed to avoid MCF outbreaks and mitigate losses. This study aimed to evaluate a sheep-associated MCF (SA-MCF) vaccine candidate targeting ovine herpesvirus 2 (OvHV-2) glycoprotein B (gB). Rabbits were used as a laboratory animal model to test the safety, immunogenicity, and protective efficacy of a chimeric virus consisting of a recombinant, non-pathogenic strain of alcelaphine herpesvirus-1 encoding OvHV-2 ORF8 to express gB (AlHV-1

Indexed as

DNA immunizationmalignant catarrhal feverovine herpesvirus-2vaccineviral-vector

Identifiers

PMID36560568
PMCPMC9786699
OpenAlexW4311687889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.