Evidence map›Paper›PMID 36560410›Full record

ArticleVaccines2022

Cytokines and Chemokines in Breastmilk of SARS-CoV-2 Infected or COVID-19 Vaccinated Mothers.

Felicia Trofin, Olivia Simona Dorneanu, Daniela Constantinescu, Eduard Vasile Nastase, Cătălina Luncă, Luminița Smaranda Iancu, Ioana-Maria Andrioaie, Alexandru Duhaniuc, Corina Maria Cianga, Mariana Pavel-Tanasa and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Felicia TrofinMicrobiology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.ORCID 0000-0002-8551-3053
Olivia Simona DorneanuMicrobiology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.ORCID 0000-0001-7720-4499
Daniela ConstantinescuImmunology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Eduard Vasile NastaseClinical Hospital of Infectious Diseases "Sf. Parascheva", 700116 Iasi, Romania.ORCID 0000-0001-6970-0097
Cătălina LuncăMicrobiology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.ORCID 0000-0001-7746-2383
Luminița Smaranda IancuMicrobiology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.ORCID 0000-0002-2592-3982
Ioana-Maria AndrioaieMicrobiology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Alexandru DuhaniucMicrobiology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Corina Maria CiangaImmunology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Mariana Pavel-TanasaImmunology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.ORCID 0000-0002-2802-5993
Dana-Teodora Anton-Păduraru"Sf. Maria" Children Emergency Hospital, 700309 Iasi, Romania.
Petru CiangaImmunology Department, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.ORCID 0000-0002-5403-2265
Grigore T. Popa University of Medicine and Pharmacy · RO

Funding

University of Medicine and Pharmacy "Grigore T. Popa" Iasi PhD
6 · The paper itself

Abstract

introductionThe COVID-19 disease and anti-SARS-CoV-2 vaccination were accompanied by alterations in several inflammatory markers. The aim of our research was to check to what extent such cytokines are transferred to infants via the breastmilk of SARS-CoV-2-infected or vaccinated mothers. Thus, we wanted to check if breastfeeding is safe during SARS-CoV-2 infection or after COVID-19 mRNA-vaccination. MATERIAL AND

methodThe Luminex Multiplexing Assay was used for quantifying 10 cytokine in the human breastmilk of SARS-CoV-2-infected or COVID-19-vaccinated mothers, compared with anti-SARS-CoV-2 IgG naïve mothers. Two milk samples were collected at 30 and 60 days either after the booster dose or afterthe onset of symptoms. A single milk sample was collected from the mothers within the control group.

resultsThe cytokine concentrations were mostly found within the reference intervals for all mothers. The status of the vaccinated/infected mother, the age of the breastfed child, the parity of the mother and the maternal age were variation factors of the above-mentioned cytokine concentrations. The type of birth and the presence of IgG in the milk had no influence on these cytokine concentrations in milk. Furthermore, no statistically significant differences were recorded between the cytokine concentrations of the two milk samples.

conclusionOur study provides data that support the safety of breastfeeding in the case of mild COVID-19 infection or after Pfizer or Moderna vaccinations.

Indexed as

antibodiesbreastmilkCOVID-19cytokinesSARS-CoV-2vaccine

Identifiers

PMID36560410
PMCPMC9784508
OpenAlexW4310036304

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.