Evidence map›Paper›PMID 36560408›Full record

ArticleVaccines2022

A Possibility of Vasospastic Angina after mRNA COVID-19 Vaccination.

Toru Awaya, Masao Moroi, Fuminori Nakamura, Satoru Toi, Momoko Wakiya, Yoshinari Enomoto, Taeko Kunimasa, Masato Nakamura

Open access · goldAbstract readCase Reports
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Toru AwayaDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Masao MoroiDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Fuminori NakamuraDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Satoru ToiDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Momoko WakiyaDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Yoshinari EnomotoDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Taeko KunimasaDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Masato NakamuraDepartment of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-22-36 Ohashi Meguro-ku, Tokyo 153-8515, Japan.
Toho University Ohashi Medical Center · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of vasospastic angina (VSA) following COVID-19 mRNA vaccination. Despite the widespread occurrence of myocarditis, there have been few reports of post-vaccinal VSA. A 41-year-old male patient was referred for chest pain at rest following mRNA vaccination; he had never experienced chest pain prior to vaccination. He was diagnosed by an acetylcholine (Ach) provocation test that showed multivessel vasospasm. After the initiation of treatment with a calcium channel blocker and nitrate, no further exacerbation of chest pain was observed. To our knowledge, this constitutes the first reported case of VSA proven by Ach provocation test after COVID-19 vaccination. The vaccination may increase coronary artery spasticity. VSA should be ruled out in post-vaccine new onset resting chest pain.

Indexed as

adverse reactionalcoholangiotensin-converting enzyme 2cardiovascular diseasesCOVID-19 vaccinationinflammatory cytokinelipid nanoparticlesvasospastic angina

Identifiers

PMID36560408
PMCPMC9786293
OpenAlexW4309930483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.