Evidence map›Paper›PMID 36559717›Full record

ArticlePolymers2022

Preparation and Synergistic Effect of Biomimetic Poly(lactic acid)/Graphene Oxide Composite Scaffolds Loaded with Dual Drugs.

Shuqiong Liu, Wanzhu Li, Zhenyi Xu, Jiapeng Hu, Fangfang Wu, Yuying Zheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shuqiong LiuCollege of Ecology and Resource Engineering, Wuyi University, Wuyishan 354300, China.ORCID 0000-0003-0379-382X
Wanzhu LiCollege of Ecology and Resource Engineering, Wuyi University, Wuyishan 354300, China.
Zhenyi XuCollege of Ecology and Resource Engineering, Wuyi University, Wuyishan 354300, China.
Jiapeng HuCollege of Ecology and Resource Engineering, Wuyi University, Wuyishan 354300, China.
Fangfang WuCollege of Ecology and Resource Engineering, Wuyi University, Wuyishan 354300, China.ORCID 0000-0002-7246-5347
Yuying ZhengCollege of Materials Science and Engineering, Fuzhou University, Fuzhou 350108, China.
Wuyi University · CNFuzhou University · CN

Funding

Education and scientific research project for young and middle-aged teachers in fujian province JAT190765Fujian Provincial Science and Technology Major Project 2021HZ027002, 2021HZ027021Fujian Provincial Science and Technology Plan Project 2020H4010;2021H4004Innovation and Entrepreneurship Training Program for college students in Fujian Province 201910397034Nanping Science and Technology Project 2022-ZXHZ-002, N2020Z015the Natural Science Foundation of Fujian Province of China 2020J01416Wuyi University Teachers and Students Co-create Research Team Project 2020-SSTD-05
6 · The paper itself

Abstract

To promote the bone repair ability of drug-loaded scaffolds, poly(lactic acid) (PLA)/graphene oxide (GO)/Salvianolic acid B (Sal-B)/aspirin (ASA) dual drug-loaded biomimetic composite scaffolds were prepared. The results showed that the addition of these two drugs delayed the gel formation of the composite system, but a biomimetic nanofiber structure could still be obtained by extending the gel time. The addition of Sal-B increased the hydrophilicity of the scaffold, while an increase in ASA reduced the porosity. Dual drug-loaded scaffolds had good haemocompatibility and synergically promoted the proliferation of MC3T3-E1 cells and enhanced alkaline phosphatase activity. Sustained-release experiments of the two drugs showed that the presence of ASA slowed the cumulative release of Sal-B, while Sal-B promoted the release of ASA. Kinetic modeling showed that the release of both drugs conforms to the Korsmeyer-Peppas model, but Sal-B conforms to the Fick diffusion mechanism and ASA follows Fick diffusion and carrier swelling/dissolution.

Indexed as

aspirinbiomimetic composite scaffoldsdual drug-loadedsalvianolic acid B

Identifiers

PMID36559717
PMCPMC9784114
OpenAlexW4311785712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.