Evidence map›Paper›PMID 36559330›Full record

ArticlePharmaceutics2022

Cytotoxicity towards Breast Cancer Cells of Pluronic F-127/Hyaluronic Acid Hydrogel Containing Nitric Oxide Donor and Silica Nanoparticles Loaded with Cisplatin.

Bianca de Melo Santana, Joana Claudio Pieretti, Rafael Nunes Gomes, Giselle Cerchiaro, Amedea Barozzi Seabra

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Frontiers in oncology · 2026
    Article
  3. Dynamic Hydrogels in Breast Tumor Models.Gels (Basel, Switzerland) · 2025
    Review
  4. Advanced Hydrogels in Breast Cancer Therapy.Gels (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Cardioprotective Effect ofMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bianca de Melo SantanaCenter for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, Brazil.ORCID 0000-0002-9848-6488
Joana Claudio PierettiCenter for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, Brazil.
Rafael Nunes GomesCenter for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, Brazil.ORCID 0000-0002-1441-4613
Giselle CerchiaroCenter for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, Brazil.ORCID 0000-0001-8606-5400
Amedea Barozzi SeabraCenter for Natural and Human Sciences, Federal University of ABC, Santo André 09210-580, Brazil.ORCID 0000-0003-0591-0380

Funding

National Council for Scientific and Technological Development 313117/2019-5São Paulo Research Foundation 2020/03646-2São Paulo Research Foundation 2020/08566-7São Paulo Research Foundation 2022/00321-0
6 · The paper itself

Abstract

The incorporation of both nitric oxide (NO) donor (S-nitrosoglutathione, GSNO) and silica nanoparticles loaded with cisplatin (SiO

Indexed as

breast cancer cellscytotoxicitydrug deliveryhydrogelnanoparticlesnitric oxide

Identifiers

PMID36559330
PMCPMC9780945

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.