Evidence map›Paper›PMID 36559300›Full record

ArticlePharmaceutics2022

Pharmacokinetic Comparison of Ginsenosides between Fermented and Non-Fermented Red Ginseng in Healthy Volunteers.

Myeong-Bae Shin, Sung-Ah Kim, Sooyoung Lee, Wang-Seob Shim, Kyung-Tae Lee, Seung-Kwon Lee, Sung-Vin Yim, Bo-Hyung Kim

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Myeong-Bae ShinDepartment of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-2838-2683
Sung-Ah KimDepartment of Clinical Pharmacology and Therapeutics, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.ORCID 0000-0003-0449-213X
Sooyoung LeeDepartment of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-4800-4348
Wang-Seob ShimKyung Hee Drug Analysis Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-0903-1386
Kyung-Tae LeeKyung Hee Drug Analysis Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-3141-3727
Seung-Kwon LeeGinseng Biotech Research Team, ILHWA Co., Ltd., Guri-si 11933, Republic of Korea.
Sung-Vin YimDepartment of Clinical Pharmacology and Therapeutics, Kyung Hee University Medical Center, Seoul 02447, Republic of Korea.ORCID 0000-0003-4393-800X
Bo-Hyung KimDepartment of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Kyung Hee University · KRKyung Hee University Medical Center · KR

Funding

Ilhwa Corporation Ilhwa CorporationMinistry of Food and Drug Safety 21153MFDS601
6 · The paper itself

Abstract

Fermentation of red ginseng (RG) produces fermented red ginseng (FRG), thereby increasing the relative amount of downstream ginsenosides, including compound Y (CY), F2, Rh2, compound K (CK), compound O, protopanaxadiol (PPD), and protopanaxatriol (PPT). These downstream ginsenosides have beneficial pharmacological effects, and are easily absorbed by the human body. Based on these expectations, a randomized, single-dose, two-period, crossover clinical trial was planned to compare the pharmacokinetic characteristics of seven types (Rb1, CY, F2, CK, Rh2, PPD, and PPT) of ginsenoside components after FRG and RG administration. The safety and tolerability profiles were assessed in this clinical trial. Sixteen healthy Korean male subjects were administered 6 g of FRG or RG. All ginsenosides except Rb1 showed higher systemic exposure after FRG administration than after RG administration, based on comparisons of ginsenoside C

Indexed as

compound Kcompound Yfermented red ginsengginsenoside absorptionpharmacokinetics

Identifiers

PMID36559300
PMCPMC9784495
OpenAlexW4311510799

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.