Evidence map›Paper›PMID 36559267›Full record

ArticlePharmaceutics2022

Advantageous Combinations of Nanoencapsulated Oregano Oil with Selected Antibiotics for Skin Treatment.

Maya Margaritova Zaharieva, Mila Kaleva, Alexander Kroumov, Marta Slavkova, Niko Benbassat, Krassimira Yoncheva, Hristo Najdenski

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Lentisk (Pharmaceutics · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Maya Margaritova ZaharievaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-8548-5649
Mila KalevaThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0002-1740-5296
Alexander KroumovThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Marta SlavkovaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Niko BenbassatFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.
Krassimira YonchevaFaculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria.ORCID 0000-0003-2704-3054
Hristo NajdenskiThe Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0003-3221-2545
Bulgarian Academy of Sciences · BGMedical University of Sofia · BG

Funding

Bulgarian Ministry of Education and Science Grant number DО1-217 from 30 November 2018, National Research Programme "Innovative Low-Toxic Bioactive Systems for Precision Medicine (BioActiveMed)
6 · The paper itself

Abstract

The aim of the present study was to evaluate the antimicrobial activity of combinations between encapsulated oregano oil and the most commonly applied antibiotics (ciprofloxacin or gentamicin) against skin infections. In particular, chitosan-alginate nanoparticles loaded with oregano oil and the selected antibiotics were included in methylcellulose hydrogels. Consistency, spreadability, pH of the hydrogel and in vitro release rate of the oil were considered appropriate for topical application. The combination of encapsulated oil and gentamicin in the hydrogel resulted in a synergistic effect against methicillin-sensitive (MSSA) and methicillin-resistant (MRSA)

Indexed as

ciprofloxacingentamicinhydrogelsMRSAnanoparticlesoregano oilskin applicationStaphylococcus aureus

Identifiers

PMID36559267
PMCPMC9780814
OpenAlexW4312126083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.