Evidence map›Paper›PMID 36559228›Full record

ArticlePharmaceutics2022

CD44-Receptor Targeted Gold-Doxorubicin Nanocomposite for Pulsatile Chemo-Photothermal Therapy of Triple-Negative Breast Cancer Cells.

Dnyaneshwar Kalyane, Suryanarayana Polaka, Nupur Vasdev, Rakesh Kumar Tekade

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dnyaneshwar KalyaneNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, An Institute of National Importance, Opposite Air Force Station, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India, Gandhinagar 382355, India.
Suryanarayana PolakaNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, An Institute of National Importance, Opposite Air Force Station, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India, Gandhinagar 382355, India.ORCID 0000-0001-7053-9392
Nupur VasdevNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, An Institute of National Importance, Opposite Air Force Station, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India, Gandhinagar 382355, India.
Rakesh Kumar TekadeNational Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, An Institute of National Importance, Opposite Air Force Station, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India, Gandhinagar 382355, India.ORCID 0000-0002-3024-3148
Government of India · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study reports the CD44 receptor-targeted gold-doxorubicin nanocomposite (TGNC-DOX) for pulsatile chemo-photothermal therapy of triple-negative breast cancer (TNBC). The developed TGNC-DOX was nanometric, having a particle size of 71.34 ± 3.66 nm. The doxorubicin was loaded by electrostatic interaction with high entrapment and loading efficiency (>75%). TGNC-DOX showed potent photothermal response and reversible photothermal stability following irradiation with 808 nm NIR laser irradiation. Further, TGNC-DOX showed laser-responsive and pH-dependent drug release behavior suggesting its suitability for chemo-photothermal therapy, specifically at the tumor microenvironment site. Cellular viability, cellular uptake, ROS generation, and apoptosis assays suggested selective localization of TGNC-DOX in cancer cells that showed a significant cytotoxic effect against MDA-MB-231 breast cancer cells. Moreover, the developed TGNC-DOX showed ferroptosis in MDA-MB-231 cells. The event of TGNC-DOX-mediated thermal ablation is marked by a significant generation of reactive oxygen species (ROS) and apoptosis, as affirmed by flow cytometry. NIR-808 laser-responsive photothermal therapy of cancer cells was found to be more effective than without NIR-808 laser-treated cells, suggesting the fundamental role of photothermal ablation. The outcome concludes developed TGNC-DOX is a novel and potential tool to mediate laser-guided chemo-photothermal ablation treatment of cancer cells.

Indexed as

breast cancerCD44 receptor targetingchemo-photothermal therapygold nanocompositeROS generationthermal ablation

Identifiers

PMID36559228
PMCPMC9787590
OpenAlexW4311785716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.