Evidence map›Paper›PMID 36559217›Full record

ArticlePharmaceutics2022

Self-Assembling Injectable Hydrogel for Controlled Drug Delivery of Antimuscular Atrophy Drug Tilorone.

Mohamed M Abdelghafour, Ágota Deák, Tamás Kiss, Mária Budai-Szűcs, Gábor Katona, Rita Ambrus, Bálint Lőrinczi, Anikó Keller-Pintér, István Szatmári, Diána Szabó and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Nanoparticle radiosensitizers in cancer radiotherapy: bridging preclinical promise and clinical reality.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Mohamed M AbdelghafourDepartment of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, H-6720 Szeged, Hungary.ORCID 0000-0002-7895-4555
Ágota DeákDepartment of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, H-6720 Szeged, Hungary.
Tamás KissInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös str. 6., H-6720 Szeged, Hungary.
Mária Budai-SzűcsInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös str. 6., H-6720 Szeged, Hungary.ORCID 0000-0001-5187-5702
Gábor KatonaInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös str. 6., H-6720 Szeged, Hungary.ORCID 0000-0003-1564-4813
Rita AmbrusInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös str. 6., H-6720 Szeged, Hungary.ORCID 0000-0001-5496-1710
Bálint LőrincziInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös str. 6, H-6720 Szeged, Hungary.
Anikó Keller-PintérDepartment of Biochemistry, Albert Szent-Györgyi Medical School, University of Szeged, H-6720 Szeged, Hungary.ORCID 0000-0002-4105-8458
István SzatmáriInstitute of Pharmaceutical Chemistry, University of Szeged, Eötvös str. 6, H-6720 Szeged, Hungary.
Diána SzabóDepartment of Oto-Rhino-Laryngology and Head & Neck Surgery, University of Szeged, Tisza Lajos krt. 111, H-6724 Szeged, Hungary.
László RovóDepartment of Oto-Rhino-Laryngology and Head & Neck Surgery, University of Szeged, Tisza Lajos krt. 111, H-6724 Szeged, Hungary.
László JanovákDepartment of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, H-6720 Szeged, Hungary.ORCID 0000-0002-2066-319X
University of Szeged · HUZagazig University · EG

Funding

Hungarian Academy of Sciences János Bolyai Research ScholarshipHungarian Scientific Research Fund OTKA FK 134684Hungarian Scientific Research Fund OTKA K 132446Joint executive program between the Arab Republic of Egypt and Hungary Mohamed M. AbdelghafourMinistry for Innovation and Technology TKP2021-EGA-28Ministry for Innovation and Technology UNKP-22-5 New National Excellence ProgramStipendium Hungaricum Mohamed M. Abdelghafour
6 · The paper itself

Abstract

A two-component injectable hydrogel was suitably prepared for the encapsulation and prolonged release of tilorone which is an antimuscular atrophy drug. The rapid (7-45 s, depending on the polymer concentration) in situ solidifications of the hydrogel were evoked by the evolving Schiff-base bonds between the aldehyde groups of modified PVA (4-formyl benzoate PVA, PVA-CHO, 5.9 mol% functionalization degree) and the amino groups of 3-mercaptopropionate chitosan (CHIT-SH). The successful modification of the initial polymers was confirmed by both FTIR and NMR measurements; moreover, a new peak appeared in the FTIR spectrum of the 10%

Indexed as

injectable self-assembled hydrogelmodified PVAmucoadhesive hydrogelprolonging drug releasethiolated chitosantilorone

Identifiers

PMID36559217
PMCPMC9782908
OpenAlexW4311633547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.