Evidence map›Paper›PMID 36559207›Full record

ArticlePharmaceutics2022

Silk-Elastin-like Polymers for Acute Intraparenchymal Treatment of the Traumatically Injured Spinal Cord: A First Systematic Experimental Approach.

Pau González, Carlos González-Fernández, Alfredo Maqueda, Virginia Pérez, Sara Escalera-Anzola, Ángel Rodríguez de Lope, Francisco Javier Arias, Alessandra Girotti, Francisco Javier Rodríguez

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Pau GonzálezLaboratory of Molecular Neurology, Hospital Nacional de Parapléjicos, 45071 Toledo, Spain.ORCID 0000-0002-8871-8054
Carlos González-FernándezLaboratory of Molecular Neurology, Hospital Nacional de Parapléjicos, 45071 Toledo, Spain.ORCID 0000-0002-3415-0723
Alfredo MaquedaLaboratory of Molecular Neurology, Hospital Nacional de Parapléjicos, 45071 Toledo, Spain.
Virginia PérezLaboratory of Molecular Neurology, Hospital Nacional de Parapléjicos, 45071 Toledo, Spain.
Sara Escalera-AnzolaSmart Devices for NanoMedicine Group University of Valladolid, 47003 Valladolid, Spain.ORCID 0000-0003-4613-711X
Ángel Rodríguez de LopeDepartment of Neurosurgery, Hospital Universitario de Toledo, 45007 Toledo, Spain.
Francisco Javier AriasSmart Devices for NanoMedicine Group University of Valladolid, 47003 Valladolid, Spain.ORCID 0000-0001-8584-3768
Alessandra GirottiSmart Devices for NanoMedicine Group University of Valladolid, 47003 Valladolid, Spain.ORCID 0000-0003-4754-7022
Francisco Javier RodríguezLaboratory of Molecular Neurology, Hospital Nacional de Parapléjicos, 45071 Toledo, Spain.ORCID 0000-0001-5902-7556
Hospital Nacional de Parapléjicos · ESUniversidad de Valladolid · ESComplejo Hospitalario Universitario de Toledo · ES

Funding

Agencia Estatal de Investigación PID2019-106386RB-I00Consejería de Educación, Cultura y Deportes de la Junta de Comunidades de Castilla-La Mancha SBPLY/19/180501/000275; ERDF co-fundedERDF A way of making Europe RTI2018-097775-B-I00Instituto de Salud Carlos III DTS19/00129Instituto de Salud Carlos III DTS19/00162Junta de Comunidades de Castilla-La Mancha/Convocatoria de Ayudas Regionales a la Investi-gación en Biomedicina y Ciencias de la Salud II-2020/03MCIN: Ministerio de Ciencia e Innovación; AEI: Agencia Estatal de Investigación. MICINN/AEI/10.13039/501100011033MICINN BES-2017-082384
6 · The paper itself

Abstract

Despite the promising potential of hydrogel-based therapeutic approaches for spinal cord injury (SCI), the need for new biomaterials to design effective strategies for SCI treatment and the outstanding properties of silk-elastin-like polymers (SELP), the potential use of SELPs in SCI is currently unknown. In this context, we assessed the effects elicited by the in vivo acute intraparenchymal injection of an SELP named (EIS)

Indexed as

(EIS)2-RGD6silk-elastin-like polymersspinal cord injury

Identifiers

PMID36559207
PMCPMC9784492
OpenAlexW4311521301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.