Evidence map›Paper›PMID 36559205›Full record

ArticlePharmaceutics2022

Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina.

Sergei Nikonov, Natalia Dolgova, Raghavi Sudharsan, Ivan Tochitsky, Simone Iwabe, Jose-Manuel Guzman, Russell N Van Gelder, Richard H Kramer, Gustavo D Aguirre, William A Beltran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Light-Activated RPE65 Inhibitors Enable On-Demand Visual Cycle Control.Journal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sergei NikonovDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Natalia DolgovaDivision of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Raghavi SudharsanDivision of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ivan TochitskyDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 90095, USA.ORCID 0000-0003-0650-9193
Simone IwabeDivision of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jose-Manuel GuzmanDivision of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Russell N Van GelderDepartment of Ophthalmology, Pathology, and Biological Structure, University of Washington, Seattle, WA 98195, USA.
Richard H KramerDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 90095, USA.
Gustavo D AguirreDivision of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
William A BeltranDivision of Experimental Retinal Therapies, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-1127-4774
University of Pennsylvania · USUniversity of California, Berkeley · USUniversity of Washington · US

Funding

NDC for the Optical Control of Biological FunctionPN2EY018241 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2006 to 2015
$37.5M
MODELS OF HEREDITY RETINAL DEGENERATIONR01EY006855 · NEI · UNIVERSITY OF PENNSYLVANIA · PI GUSTAVO David AGUIRRE, William A. Beltran · 1992 to 2026
$20.7M
Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
UC Berkeley Vision Science COREP30EY003176 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RICHARD H KRAMER · 1985 to 2026
$16.4M
Photoswitchable channel blockers for treatment of blindnessR24EY023937 · NEI · UNIVERSITY OF WASHINGTON · PI VAN GELDER, RUSSELL N. · 2014 to 2018
$6.1M
Understanding how photoswitches restore visual function in blindnessR01EY024334 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRAMER, RICHARD H · 2015 to 2024
$4.4M
Light-activated ion chanenls for remote control of neuronal activityR01EY018957 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRAMER, RICHARD H · 2008 to 2011
$1.6M
Foundation Fighting Blindness Penn Large Animal Model Translational & Research CenterNEI NIH HHS P30 EY001583NEI NIH HHS P30 EY003176NEI NIH HHS PN2 EY018241NEI NIH HHS R01 EY006855NEI NIH HHS R01 EY018957NEI NIH HHS R01 EY024334NEI NIH HHS R24 EY023937NIH HHS P30EY001583NIH HHS PN2EY018241NIH HHS R24EY023937NIH HHS RO1EY006855
6 · The paper itself

Abstract

Photopharmacological compounds such as azobenzene-based photoswitches have been shown to control the conductivity of ionic channels in a light-dependent manner and are considered a potential strategy to restore vision in patients with end-stage photoreceptor degeneration. Here, we report the effects of DENAQ, a second-generation azobenzene-based photoswitch on retinal ganglion cells (RGC) in canine retinas using multi-electrode array (MEA) recordings (from nine degenerated and six WT retinas). DENAQ treatment conferred increased light sensitivity to RGCs in degenerated canine retinas. RGC light responses were observed in degenerated retinas following ex vivo application of 1 mM DENAQ (

Indexed as

canineDENAQphotopharmacologyphotoswitchretinal degenerationvision restoration

Identifiers

PMID36559205
PMCPMC9783220
OpenAlexW4311521200

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.