Evidence map›Paper›PMID 36559126›Full record

ArticlePharmaceutics2022

Nanocrystal Preparation of Poorly Water-Soluble Drugs with Low Metal Contamination Using Optimized Bead-Milling Technology.

Hironori Tanaka, Yuya Ochii, Yasushi Moroto, Daisuke Hirata, Tetsuharu Ibaraki, Ken-Ichi Ogawara

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hironori TanakaFormulation R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki 660-0813, Hyogo, Japan.ORCID 0000-0001-7302-3631
Yuya OchiiFormulation R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki 660-0813, Hyogo, Japan.
Yasushi MorotoFormulation R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki 660-0813, Hyogo, Japan.
Daisuke HirataHiroshima Metal & Machinery Co., Ltd., Hiroshima 737-0144, Hiroshima, Japan.
Tetsuharu IbarakiHiroshima Metal & Machinery Co., Ltd., Hiroshima 737-0144, Hiroshima, Japan.
Ken-Ichi OgawaraLaboratory of Pharmaceutics, Kobe Pharmaceutical University, Kobe 658-8558, Hyogo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanocrystal preparation using bead milling is an important technology to enhance the solubility of poorly water-soluble drugs. However, there are safety concerns regarding the metal contaminants generated during bead milling. We have previously reported optimized bead-milling parameters that could minimize metal contamination and demonstrated comparable performance to NanoCrystal

Indexed as

bead millingdrug nanocrystalmetal contaminationmilling parametersphysicochemical properties

Identifiers

PMID36559126
PMCPMC9783641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.