ArticlePharmaceutics2022
Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation.
Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Optimization of gemifloxacin immediate-release tablets using quality by design.Journal of food and drug analysis · 2026Article
- Optimization of Xiaoer Lingyin granule formulation using single-factor and response surface methodology.RSC advances · 2026Article
- Effect of Critical Process Parameters on the Granule Quality During a Binder-Free High-Shear Wet Granulation Process of Mesoporous Silica Microparticles While Achieving Core-Shell Structured Granules.Pharmaceuticals (Basel, Switzerland) · 2026Article
- A Formulation-Process-Product Integrated Design Method for Accelerating Pharmaceutical Tablet Development via the High-Shear Wet Granulation and Tableting Route.Pharmaceutics · 2025Article
- Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling.Pharmaceutics · 2024Article
- A tabletability change classification system in supporting the tablet formulation design via the roll compaction and dry granulation process.International journal of pharmaceutics: X · 2023Article
- The Influence of Wet Granulation Parameters on the Compaction Behavior and Tablet Strength of a Hydralazine Powder Mixture.Pharmaceutics · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Understanding the tabletability change of materials after granulation is critical for the formulation and process design in tablet development. In this paper, a material library consisting of 30 pharmaceutical materials was used to summarize the pattern of change of tabletability during high shear wet granulation and tableting (HSWGT). Each powdered material and the corresponding granules were characterized by 19 physical properties and nine compression behavior classification system (CBCS) parameters. Principal component analysis (PCA) was used to compare the physical properties and compression behaviors of ungranulated powders and granules. A new index, namely the relative change of tabletability (
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Registered trials
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