ArticlePharmaceutics2022
Design of Reservoirs Enabling Stress-Induced Sequential Release Systems.
Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
Mechanical stress is recognized as a principle for opening enclosed compartments through compression, stretching, or shear, eventually resulting in the onset of a diffusion-controlled release. Here, we hypothesized that the geometrical design of cavities (cut-outs) introduced as containers in elastic polymer substrates and sealed with a brittle coating layer would enable a pre-defined release of different compounds by stress concentration phenomena. Design criteria such as cut-out shapes, orientations, and depths were initially assessed for suitably different stress concentrations in computational models. In substrates fabricated from polydimethylsiloxane by photolithographic techniques, the local strains at horizontal rectangular, circular, and vertical rhombus-shaped cut-outs systematically increased under horizontal stretching as proposed. When filled with model compounds and coated with poly(
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Registered trials
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