Evidence map›Paper›PMID 36559098›Full record

ArticlePharmaceutics2022

Prediction of Drug-Drug-Gene Interaction Scenarios of (

Christina Kovar, Lukas Kovar, Simeon Rüdesheim, Dominik Selzer, Boian Ganchev, Patrick Kröner, Svitlana Igel, Reinhold Kerb, Elke Schaeffeler, Thomas E Mürdter and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Christina KovarClinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0003-0155-9861
Lukas KovarClinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0003-1832-5498
Simeon RüdesheimClinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-5741-2511
Dominik SelzerClinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.
Boian GanchevDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Patrick KrönerDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Svitlana IgelDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Reinhold KerbDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Elke SchaeffelerDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Thomas E MürdterDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Matthias SchwabDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.
Thorsten LehrClinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany.ORCID 0000-0002-8372-1465
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology · DESaarland University · DE

Funding

European Commission Horizon 2020 UPGx 668353German Federal Ministry of Education and Research (BMBF) 031L0188DRobert Bosch Stiftung, Stuttgart, Germany
6 · The paper itself

Abstract

Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. However, since (

Indexed as

clomiphenecytochrome P450 2D6 (CYP2D6) polymorphismsdrug–drug–gene interactions (DDGIs)drug–drug interactions (DDIs)drug–gene interactions (DGIs)(E)-clomiphenepharmacokineticsphysiologically based pharmacokinetic (PBPK) modeling

Identifiers

PMID36559098
PMCPMC9781104
OpenAlexW4310214801

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.