ReviewPharmaceuticals (Basel, Switzerland)2022
Water as Green Solvent: Methods of Solubilisation and Extraction of Natural Products-Past, Present and Future Solutions.
Review in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Antibiofilm activity against common pathogenic bacteria in Thailand and liquid chromatography-quadrupole time-of-flight mass spectrometry chemical profiling of Ha-Rak formula and its components: an in vitro study.BMC complementary medicine and therapies · 2026Article
- Solvent-Dependent GC-MS Fingerprinting of Lipophilic Constituents inMolecules (Basel, Switzerland) · 2026Article
- Metal-Free, Chemoselective Reduction of Aromatic Nitro Compounds in Water at Room Temperature.ChemistryOpen · 2026Article
- Recent Developments in Sustainable Solubilization.ChemSusChem · 2026Article
- Chemoselective Difluorination of Tetramic Acids in Water.ACS omega · 2026Article
- Preclinical Evaluation ofMolecules (Basel, Switzerland) · 2026Article
- Solvent Extraction of Metals in the Circular Economy: Enhancing Resource Efficiency and Sustainability.TheScientificWorldJournal · 2026Review
- A deep dive into herbal extraction: Techniques, trends, and technological advancements.South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges · 2026Article
- A comparative analysis of Fagonia indica extracts and green synthesized nanoparticles for the determination of antioxidant potential.Scientific reports · 2025Article
- Comparative study of polyphenol extraction using physical techniques and water as a solvent: a sustainable approach for the valorization of apple pomace.Environmental science and pollution research international · 2025Article
- Extraction of Marine Bioactive Compounds from Seaweed: Coupling Environmental Concerns and High Yields.Marine drugs · 2025Review
- Bacillus toyonensis BAR1, a yellow-pigment producing endophyte of Berberis aristata DC: a potential source of bioactive and antimicrobial compounds.Folia microbiologica · 2025Article
- Antibacterial activity of fungus comb extracts from Senegalese fungus-farming termites.AMB Express · 2025Article
- Innovative Approaches to Extracting Phenolics fromFoods (Basel, Switzerland) · 2025Article
- Water Effect on the Photochemistry of Arylazo Sulfonates.The Journal of organic chemistry · 2025Article
- Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism.Ultrasonics sonochemistry · 2025Article
- Plant bioactive compounds: extraction, biological activities, immunological, nutritional aspects, food application, and human health benefits-A comprehensive review.Frontiers in nutrition · 2025Review
- Schiff Bases Derived from Pyridoxal 5'-Phosphate and 2-X-Phenylamine (X = H, OH, SH): Substituent Effects on UV-Vis Spectra and Hydrolysis Kinetics.Molecules (Basel, Switzerland) · 2024Article
- Investigation of the Functional Components in Health Beverages Made fromMetabolites · 2024Article
- Comparative Cytotoxicity Evaluation of Heat-AssistedFood technology and biotechnology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water is considered the greenest solvent. Nonetheless, the water solubility of natural products is still an incredibly challenging issue. Indeed, it is nearly impossible to solubilize or to extract many natural products properly using solely water due to their low solubility in this solvent. To address this issue, researchers have tried for decades to tune water properties to enhance its solvent potential in order to be able to solubilise or extract low-water solubility compounds. A few methods involving the use of solubilisers were described in the early 2000s. Since then, and particularly in recent years, additional methods have been described as useful to ensure the effective green extraction but also solubilisation of natural products using water as a solvent. Notably, combinations of these green methods unlock even higher extraction performances. This review aims to present, compare and analyse all promising methods and their relevant combinations to extract natural products from bioresources with water as solvent enhanced by green solubilisers and/or processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.