ReviewPharmaceuticals (Basel, Switzerland)2022
Lactic Acidosis Related to Pharmacotherapy and Human Diseases.
Review in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06121908 (Role of Blood Lactate Level in Prediction of Outcome of Cirrhotic Patients at The Intensive Care Unit), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Blood Lactate Level in Prediction of Outcome of Cirrhotic Patients at The Intensive Care Unit
Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Type B Lactic Acidosis: Diagnosis, Etiology and Treatment - An Educational Review.Cardiology research · 2026Review
- Diffuse large B-cell lymphoma combined with hyperlactatemia presents high mortality: case report and literature review.MedScience · 2026Review
- Modern management of maxillofacial trauma in the emergency department.World journal of emergency medicine · 2026Review
- Evaluating the potential of ChatGPT as an educational decision-support tool for hemodialysis decision-making in nephrology training.Frontiers in medicine · 2026Article
- Evolving Trends and Drug Class Dynamics in Drug-Induced Myocarditis: A 2-Decade Comparative Analysis of Pharmacovigilance Data.Journal of the American Heart Association · 2025Article
- Contribution of albumin-corrected anion gap and associated biomarkers to the mortality of patients with congestive heart failure: a retrospective cohort study.BMC cardiovascular disorders · 2025Article
- BRASH syndrome: a systematic review of clinical manifestations and associated risk factors.World journal of emergency medicine · 2025Article
- Acute Normovolemic Hemodilution Changes the Aquaporin Expression Profile in Specific Tissues and Induces Apoptotic and Inflammatory Processes in a Rat Model.Medicina (Kaunas, Lithuania) · 2025Article
- Lactate and lactylation in the kidneys: Current advances and prospects (Review).International journal of molecular medicine · 2025Review
- Clinical Pharmacology of Loop Diuretics in Critical Care.Clinical pharmacokinetics · 2025Review
- Clinical features and risk factors of older adults with bloodstream infection.BMC geriatrics · 2025Article
- Possible iodophor-induced systemic iodine toxicity during transurethral seminal vesiculoscopy: a case report and literature review.BMC urology · 2025Review
- Persistent Lactate Elevation in a Patient with Asthma Exacerbation and a Congenital Portosystemic Shunt: A Case Report and Literature Review.Reports (MDPI) · 2025Article
- The relationship between lactate/albumin ratio and prognosis in children with acute kidney injury.PloS one · 2025Article
- Risk of medication-induced lactic acidosis and hyperlactatemia: a pharmacovigilance study of the United States Food and Drug Administration's Adverse Event Reporting System database.Frontiers in pharmacology · 2025Article
- Risk factors for failed extubation within 7 days in elderly critically ill patients based on respiratory mechanics and clinical indicators: a retrospective cohort study.Frontiers in medicine · 2025Article
- Predictive Value of Normalized Lactate Load for Patients with Acute Type A Aortic Dissection: Based on the MIMIC-IV Database.Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia · 2025Article
- Metformin: Beyond Type 2 Diabetes Mellitus.Cureus · 2024Review
- A Case of Acute Human Self-Poisoning With Bispyribac Sodium Presenting as Lactic Acidosis.Cureus · 2024Article
- Unmasking the Rarity: A Case Report on Type B Lactic Acidosis in Pediatric Acute Lymphoblastic Leukemia.Cureus · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lactic acidosis represents one of the most common conditions that can compromise the health of intensive care unit (ICU) patients, increasing the mortality of patients with high levels of Lactate who do not receive a proper treatment within the first 6 h of hospitalization. There are two enantiomers of lactic acid: L-lactic acid (when the concentration increases, it can lead to a state of severe acidemia risking cardiovascular collapse, causing an increase in mortality in ICU patients) and D lactic acid (produced in the human organism by microbiota and its production increases during some pathological status). Generally, increased levels of serum lactic acid could be due to numerous factors, including hypoxia (caused for example by septic/cardiogenic/hypovolemic or obstructive shock), specific pathologies (e.g., liver disease), use of some drugs (e.g., metformin), presence of toxins, and trauma. Since the underlying cause could be fatal for the ICU patient, it is important to understand the root of this clinical status with a view to correct it and prevent the risk of a poor clinical outcome. Prevention and early treatment are the keys to control the negative clinical consequences. The aim of this review is to revise the scientific literature for further confirmation about the importance of early identification of acidotic statuses and to underline how an early diagnosis can prevent the worst clinical outcome, especially for ICU patients who are more fragile compared to the general population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.