Evidence map›Paper›PMID 36558946›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

4-Isobutylmethcathinone-A Novel Synthetic Cathinone with High In Vitro Cytotoxicity and Strong Receptor Binding Preference of Enantiomers.

Martin Paškan, Silvie Rimpelová, Vladimíra Svobodová Pavlíčková, Dita Spálovská, Vladimír Setnička, Martin Kuchař, Michal Kohout

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. ExperimentalMolecules (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Martin PaškanDepartment of Organic Chemistry, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.
Silvie RimpelováDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.ORCID 0000-0002-3008-1396
Vladimíra Svobodová PavlíčkováDepartment of Biochemistry and Microbiology, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.ORCID 0000-0003-1055-4026
Dita SpálovskáDepartment of Analytical Chemistry, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.ORCID 0000-0001-9503-6329
Vladimír SetničkaDepartment of Analytical Chemistry, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.
Martin KuchařForensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology, 166 28 Prague, Czech Republic.ORCID 0000-0002-7616-6352
Michal KohoutDepartment of Organic Chemistry, University of Chemistry and Technology Prague, 166 28 Prague, Czech Republic.ORCID 0000-0003-1447-4453
University of Chemistry and Technology, Prague · CZ

Funding

Czech Science Foundation 21-31139J
6 · The paper itself

Abstract

New psychoactive substances and among them synthetic cathinones represent a significant threat to human health globally. However, within such a large pool of substances derived from a natural compound ((

Indexed as

absolute configurationchiral drugschiral separationcytotoxicitydensity functional theory calculationsenantiomer-selective binding to receptorsneurotoxicityreceptor binding studiessynthetic cathinones

Identifiers

PMID36558946
PMCPMC9780888
OpenAlexW4310378672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.