ArticlePathogens (Basel, Switzerland)2022
Immunopathology of Renal Tissue in Fatal Cases of Dengue in Children.
Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis.Frontiers in immunology · 2025Article
- The Innate Immune Response in DENV- and CHIKV-Infected Placentas and the Consequences for the Fetuses: A Minireview.Viruses · 2023Review
- Primary infection of BALB/c mice with a dengue virus type 4 strain leads to kidney injury.Memorias do Instituto Oswaldo Cruz · 2023Article
- Liver immunopathogenesis in fatal cases of dengue in children: detection of viral antigen, cytokine profile and inflammatory mediators.Frontiers in immunology · 2023Article
- Common arboviruses and the kidney: a review.Jornal brasileiro de nefrologiaReview
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Dengue virus (DENV) infection represents a worldwide public health concern and can cause damage to multiple organs, including the kidney. In this work, we investigated the histopathological changes caused by dengue virus infection along with the detection of inflammatory mediators, cytokines, and cell expression patterns in the renal tissue of three fatal cases in children. Hematoxylin and Eosin staining was performed to analyze these histopathological changes. Immunohistochemistry allowed for the detection of immunological inflammatory markers in renal tissues that were quantified and further analyzed. Vascular congestion, edema and glomerular infiltrate were observed in the three cases, in addition to the thickening of the matrix area around the glomerular capillaries and mononuclear infiltrate associated with vascular congestion in the medullary region. The renal tissues exhibited collagen deposition and high expression of CD68
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