Evidence map›Paper›PMID 36558864›Full record

ArticlePathogens (Basel, Switzerland)2022

Progress of the COVID-19: Persistence, Effectiveness, and Immune Escape of the Neutralizing Antibody in Convalescent Serum.

Dan Liang, Guanting Zhang, Mingxing Huang, Li Wang, Wenshan Hong, An'an Li, Yufeng Liang, Tao Wang, Jiahui Lu, Mengdang Ou and 7 more

Open access · goldAbstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Dan LiangGuangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou 510632, China.
Guanting ZhangGuangdong Provincial Center for Disease Control and Prevention, Guangdong Workstation for Emerging Infectious Disease Control and Prevention, Guangzhou 511430, China.
Mingxing HuangThe Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Li WangSchool of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Wenshan HongMPH Education Center, Shantou University Medical College, Shantou 515041, China.
An'an LiSchool of Public Health, Southern Medical University, Guangzhou 510515, China.
Yufeng LiangSchool of Public Health, Southern Medical University, Guangzhou 510515, China.
Tao WangMPH Education Center, Shantou University Medical College, Shantou 515041, China.
Jiahui LuThe Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.ORCID 0000-0003-2159-615X
Mengdang OuThe Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Zhongqiang RenSecond People's Hospital of Zhongshan, Zhongshan 528447, China.
Huiyi LuSecond People's Hospital of Zhongshan, Zhongshan 528447, China.
Rutian ZhengHuizhou Central People's Hospital, Huizhou 516001, China.
Xionghui CaiHuizhou Central People's Hospital, Huizhou 516001, China.
Xingfei PanDepartment of Infectious Diseases, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China.
Jinyu XiaThe Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Changwen KeEmergency Key Team, Guangzhou National Laboratory, Guangzhou 510700, China.
Sun Yat-sen University · CNHuizhou Central People's Hospital · CNShantou University · CNSouthern Medical University · CNZhongshan City Second People's Hospital · CNGuangdong Provincial Center for Disease Control and Prevention · CNJinan University · CNThird Affiliated Hospital of Guangzhou Medical University · CN

Funding

NIEHS NIH HHS 27300C0032
6 · The paper itself

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a new coronavirus causing Coronavirus Disease 2019 (COVID-19), is a major topic of global human health concern. The Delta and Omicron variants have caused alarming responses worldwide due to their high transmission rates and a number of mutations. During a one-year follow-up (from June 2020 to June 2021), we included 114 patients with SARS-CoV-2 infection to study the long-term dynamics and the correlative factors of neutralizing antibodies (NAbs) in convalescent patients. The blood samples were collected at two detection time points (at 6 and 12 months after discharge). We evaluated the NAbs response of discharged patients by performing a micro-neutralization assay using a SARS-CoV-2 wild type. In addition, a total of 62 serum samples from discharged COVID-19 patients with Alpha, Beta, Delta, and Omicron variants of infection were enrolled to perform cross-neutralization tests using the original SARS-CoV-2 strain and VOCs variants (including Alpha, Beta, Gamma, Delta, and Omicron variants) and to assess the ability of NAbs against the SARS-CoV-2 variants. NAbs seroconversion occurred in 91.46% of patients (

Indexed as

COVID-19kineticsneutralizing antibodySARS-CoV-2SARS-CoV-2 variantsvaccination

Identifiers

PMID36558864
PMCPMC9782332
OpenAlexW4311378020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.