Evidence map›Paper›PMID 36558533›Full record

ReviewNutrients2022

Protective Role of Natural Compounds under Radiation-Induced Injury.

Annamaria Altomare, Michele Fiore, Gabriele D'Ercole, Elena Imperia, Roberta Maria Nicolosi, Susanna Della Posta, Gabriella Pasqua, Michele Cicala, Laura De Gara, Sara Ramella and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Annamaria AltomareUnit of Food Science and Nutrition, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0001-8630-7836
Michele FioreOperative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0003-1889-4578
Gabriele D'ErcoleOperative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0002-5796-7525
Elena ImperiaUnit of Food Science and Nutrition, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Roberta Maria NicolosiDepartment of Environmental Biology, Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Susanna Della PostaUnit of Food Science and Nutrition, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0003-0085-8448
Gabriella PasquaDepartment of Environmental Biology, Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
Michele CicalaResearch Unit of Gastroenterology, Università Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0002-5370-2642
Laura De GaraUnit of Food Science and Nutrition, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.ORCID 0000-0001-5938-7113
Sara RamellaOperative Research Unit of Radiation Oncology, Fondazione Policlinico Universitario Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Michele Pier Luca GuarinoResearch Unit of Gastroenterology, Università Campus Biomedico di Roma, Via Alvaro del Portillo 21, 00128 Rome, Italy.
Università Campus Bio-Medico · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, evidence has shown the potential therapeutic effects of different natural compounds for the prevention and treatment of radiotherapy-induced mucositis (RIOM). RIOM represents one of the most frequent side effects associated with anti-neoplastic treatments affecting patients' quality of life and treatment response due to radiation therapy discontinuation. The innate radio-protective ability of natural products obtained from plants is in part due to the numerous antioxidants possessed as a part of their normal secondary metabolic processes. However, oxygen presence is a key point for radiation efficacy on cancer cells. The aim of this review is to describe the most recent evidence on radiation-induced injury and the emerging protective role of natural compounds in preventing and treating this specific damage without compromising treatment efficacy.

Indexed as

MucositisRadiation InjuriesStomatitisAntioxidantsHumansQuality of LifeAntioxidantsmucositisnatural compoundsradiation-induced mucositisradioprotectiveradiotherapy

Identifiers

PMID36558533
PMCPMC9786992
OpenAlexW4312210653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.