Evidence map›Paper›PMID 36558493›Full record

ArticleNutrients2022

Effects of Different Doses, Forms, and Frequencies of Zinc Supplementation on Biomarkers of Iron and Zinc Status among Young Children in Dhaka, Bangladesh.

M Munirul Islam, Robert E Black, Nancy F Krebs, Jamie Westcott, Julie M Long, Kazi M Islam, Janet M Peerson, Rahvia Alam Sthity, Afsana Mim Khandaker, Mehedi Hasan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

M Munirul IslamNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Robert E BlackInternational Zinc Nutrition Consultative Group, University of California, San Francisco, CA 94609, USA.
Nancy F KrebsInternational Zinc Nutrition Consultative Group, University of California, San Francisco, CA 94609, USA.
Jamie WestcottDepartment of Pediatrics, Denver Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.ORCID 0000-0002-0549-3145
Julie M LongDepartment of Pediatrics, Denver Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
Kazi M IslamNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Janet M PeersonIndependent Consultant, Davis, CA 95616, USA.
Rahvia Alam SthityNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0001-5988-358X
Afsana Mim KhandakerNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0001-6045-6200
Mehedi HasanNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.ORCID 0000-0003-2029-2795
Shams El ArifeenNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Tahmeed AhmedNutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka 1212, Bangladesh.
Janet C KingInternational Zinc Nutrition Consultative Group, University of California, San Francisco, CA 94609, USA.
Christine M McDonaldInternational Zinc Nutrition Consultative Group, University of California, San Francisco, CA 94609, USA.ORCID 0000-0003-1231-9003
International Centre for Diarrhoeal Disease Research · BDUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · USJohns Hopkins University · USUniversity of California, Davis · US

Funding

Bill & Melinda Gates Foundation OPP1150161
6 · The paper itself

Abstract

Young children in resource-constrained settings are susceptible to zinc deficiency and its deleterious health effects. The objective of this secondary analysis was to evaluate the effects of the following six interventions on biomarkers of iron and zinc status among a subgroup of young children in Dhaka, Bangladesh, who participated in the Zinc in Powders Trial (ZiPT): (1) standard micronutrient powders (MNPs) containing 4.1 mg zinc and 10 mg iron, daily; (2) high-zinc (10 mg) and low-iron (6 mg) (HiZn LoFe) MNP, daily; (3) HiZn (10 mg) and LoFe (6 mg)/HiZn (10 mg) and no-iron MNPs on alternating days; (4) dispersible zinc tablet (10 mg), daily; (5) dispersible zinc tablet (10 mg), daily for 2 weeks at enrollment and at 12 weeks; (6) placebo powder, daily. At the end of the 24 week intervention period, children in the daily dispersible zinc tablet group exhibited a mean serum zinc concentration (SZC) of 92.5 μg/dL, which was significantly higher than all other groups except the HiZn LoFe MNP alternating group (81.3 μg/dL). MNPs containing 10 mg and 6 mg of iron had a similar impact on biomarkers of iron status, with no evidence of an adverse interaction with zinc.

Indexed as

Anemia, Iron-DeficiencyTrace ElementsBangladeshBiomarkersChildChild, PreschoolDietary SupplementsHumansInfantMicronutrientsPowdersTabletsZincBiomarkersMicronutrientsPowdersTabletsTrace ElementsZincBangladeshbiomarkermicronutrientszinc

Identifiers

PMID36558493
PMCPMC9781687
OpenAlexW4312194674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.