ArticleNutrients2022
The Circadian Syndrome Is a Significant and Stronger Predictor for Cardiovascular Disease than the Metabolic Syndrome-The NHANES Survey during 2005-2016.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Relationship between depressive symptom trajectories and cardiovascular disease risk in middle-aged and older adults with cardiovascular-kidney-metabolic syndrome stages 0-3.BMC cardiovascular disorders · 2026Article
- Associations between multiple metabolic indices and circadian syndrome: a cross-sectional study with mediation analysis of the C-reactive protein triglyceride glucose index.Hormones (Athens, Greece) · 2026Article
- Hyperuricemia as a Biomarker for Circadian Syndrome: A Cross-Sectional Study.Clocks & sleep · 2026Article
- Association between relative muscle strength and circadian syndrome among middle-aged and older Chinese adults.Scientific reports · 2026Article
- Non-traditional metabolic indices predict incident circadian syndrome in middle-aged and older Chinese adults: a nationwide prospective cohort study and machine learning analysis.Lipids in health and disease · 2026Observational
- The influence of physical activity on circadian syndrome: a nationwide prospective study based on the CHARLS cohort.BMC public health · 2026Article
- Coffee consumption in relation to circadian syndrome in US population: a cross-sectional study.Nutrition journal · 2026Article
- Vitamin D as a Regulator of the Biological Clock-Implications for Circadian-Metabolic Dysregulation.International journal of molecular sciences · 2026Review
- Association between systemic immune-inflammatory index and circadian syndrome: Data from NHANES 2005 to 2018.Medicine · 2026Article
- Circadian syndrome (CircS) and cognitive trajectory deterioration in middle-aged and older adults: A national cohort study with causal forest analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Circadian syndrome, not metabolic syndrome, is a significant predictor of mild cognitive impairment in middle-aged and older adults - The CHARLS survey during 2015-2018.BMC public health · 2026Article
- Association of Circadian Syndrome with Incident Risk of 23 Site-Specific Cancers: A Large-Scale Prospective Study in the UK Biobank.Research (Washington, D.C.) · 2026Article
- Joint Association of Cholesterol, High-Density Lipoprotein and Glucose Index, and Circadian Syndrome With Incidence of Cardiovascular Disease: Results From National Longitudinal Prospective Studies.Cardiovascular therapeutics · 2026Article
- Comparative Evaluation of Metabolic Syndrome, Circadian Syndrome, and Allostatic Load Measures on All-Cause Mortality in U.S. Males and Females.International journal of endocrinology · 2026Article
- Circadian Syndrome Mediates the Association Between Body Roundness Index and Incident Stroke Risk in Middle-Aged and Older Chinese Adults: A Nationwide Prospective Cohort Study.Behavioural neurology · 2026Article
- The relationship between social risk profile of middle-aged and older adults in the united States and circadian syndrome and all-cause mortality: evidence from NHANES 2007-2018.BMC public health · 2025Article
- The association between magnesium intake and circadian syndrome among US adults attending NHANES 2005-2016.Nutrition journal · 2025Article
- Exploring social determinants of health in the context of metabolic and circadian influences on new hip fracture risk: longitudinal insights from CHARLS.BMC public health · 2025Article
- UK Biobank study of the association between circadian syndrome and cardio-kidney events or all-cause mortality.Communications medicine · 2025Article
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Authors and funding
10 authors at 7 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aimed to compare the predictive value of the Circadian Syndrome (CircS) and Metabolic Syndrome (MetS) for cardiovascular disease (CVD). We used data of 12,156 adults aged ≥20 years who attended National Health and Nutrition Examination Survey (NHANES) 2005-2016. Mortality was obtained from the registry updated to 2019. The CircS was defined based on components of the MetS, in addition to short sleep and depression. Both the MetS and CircS were directly associated with self-reported history of CVD. The odds ratios for prevalent CVD associated with the CircS and MetS, respectively, were 2.92 (95% confidence interval (CI) 2.21-3.86) and 3.20 (2.38-4.30) in men, and 3.27 (2.34-4.59) and 3.04 (2.15-4.30) in women. The CircS had a better predictive power for prevalent CVD than that of MetS, as indicated by the higher positive predictive value (PPV); in men, the PPV for prevalent CVD with CircS was 23.1% and with MetS 20.9%, and in women these were 17.9% vs. 16.4%, respectively. However, the PPV of the CircS and MetS did not differ for the CVD mortality prediction. Women with CircS alone had a higher risk for both prevalent CVD and CVD mortality than those with MetS alone. In conclusion, the CircS is a significant and stronger predictor for CVD than the MetS in US adults.
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