Evidence map›Paper›PMID 36558405›Full record

ArticleNutrients2022

Plasma Concentrations of Short-Chain Fatty Acids in Active and Recovered Anorexia Nervosa.

Jingjing Xu, Rikard Landberg, Catharina Lavebratt, Cynthia M Bulik, Mikael Landén, Ida A K Nilsson

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Jingjing XuDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-4019-7181
Rikard LandbergDepartment of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, 412 96 Gothenburg, Sweden.
Catharina LavebrattDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.
Cynthia M BulikCentre for Eating Disorders Innovation, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0001-7772-3264
Mikael LandénDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden.
Ida A K NilssonDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0002-7676-4299
Karolinska University Hospital · SEChalmers University of Technology · SEKarolinska Institutet · SEUniversity of North Carolina at Chapel Hill · US

Funding

Brain and Behavior Research Foundation Distinguished Investigator Grant XXHjärnfonden FO2019-0122Karolinska Institute XXKlarman Family Foundation XXLundbeck Foundation R276-2018-4581NIMH NIH HHS R01MH120170; R01MH124871; R01MH119084; R01MH118278; R01 MH124871Swedish Foundation for Strategic Research KF10-0039Swedish Research Council 2018-02653; 538-2013-8864Wenner-Gren Foundations SSv2019-0008
6 · The paper itself

Abstract

Anorexia nervosa (AN) is one of the most lethal psychiatric disorders. To date, we lack adequate knowledge about the (neuro)biological mechanisms of this disorder to inform evidence-based pharmacological treatment. Gut dysbiosis is a trending topic in mental health, including AN. Communication between the gut microbiota and the brain is partly mediated by metabolites produced by the gut microbiota such as short-chain fatty acids (SCFA). Previous research has suggested a role of SCFA in weight regulation (e.g., correlations between specific SCFA-producing bacteria and BMI have been demonstrated). Moreover, fecal SCFA concentrations are reported to be altered in active AN. However, data concerning SCFA concentrations in individuals who have recovered from AN are limited. In the present study, we analyzed and compared the plasma concentrations of seven SCFA (acetic-, butyric-, formic-, isobutyric-, isovaleric-, propionic-, and succinic acid) in females with active AN (

Indexed as

Anorexia NervosaBacteriaFatty Acids, VolatileFecesFemaleHumansFatty Acids, Volatileanorexia nervosaBMIplasmashort-chain fatty acids

Identifiers

PMID36558405
PMCPMC9781195
OpenAlexW4311975012

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.