Molecular Networking and Cultivation Profiling Reveals Diverse Natural Product Classes from an Australian Soil-Derived Fungus

Taizong Wu, Angela A Salim, Paul V Bernhardt, Robert J Capon

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Taizong WuInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Angela A SalimInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Paul V BernhardtSchool of Chemistry and Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.

Robert J CaponInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-8341-7754

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study showcases the application of an integrated workflow of molecular networking chemical profiling (GNPS), together with miniaturized microbioreactor cultivation profiling (MATRIX) to successfully detect, dereplicate, prioritize, optimize the production, isolate, characterize, and identify a diverse selection of new chemically labile natural products from the Queensland sheep pasture soil-derived fungus

Indexed as

Biological ProductsAnimalsAspergillusAustraliaMolecular StructureSheepBiological ProductsaflaquinoloneaspergillamideAspergillusaspulvinaspulvinoneasterriquinoneAustralian soil-derived fungusGNPS molecular networkingMATRIX cultivation

Identifiers

PMID36558198

DOI10.3390/molecules27249066

PMCPMC9786664

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.