Evidence map›Paper›PMID 36558176›Full record

ReviewMolecules (Basel, Switzerland)2022

Phytochemical Compounds and Nanoparticles as Phytochemical Delivery Systems for Alzheimer's Disease Management.

Saad Bakrim, Sara Aboulaghras, Naoual El Menyiy, Nasreddine El Omari, Hamza Assaggaf, Learn-Han Lee, Domenico Montesano, Monica Gallo, Gokhan Zengin, Yusra AlDhaheri and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Mechanisms Underlying the Cognitive Benefits ofPlants (Basel, Switzerland) · 2025
    Article
  7. Review
  8. Nanoparticles as an Encouraging Therapeutic Approach to Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  9. Review
  10. Elucidating Anti-aging and Antioxidant Activity ofCombinatorial chemistry & high throughput screening · 2025
    Article
  11. Recent advances in anti-infective drug discovery · 2025
    Article
  12. Review
  13. The Therapeutic Potential ofPharmaceuticals (Basel, Switzerland) · 2024
    Review
  14. Review
  15. Role of phytocompounds as the potential anti-viral agent: an overview.Naunyn-Schmiedeberg's archives of pharmacology · 2023
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 6 countries.

Saad BakrimGeo-Bio-Environment Engineering and Innovation Laboratory, Molecular Engineering, Biotechnology and Innovation Team, Polydisciplinary Faculty of Taroudant, Ibn Zohr University, Agadir 80000, Morocco.ORCID 0000-0002-4521-3515
Sara AboulaghrasPhysiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research, Mohammed V University in Rabat, Rabat 10100, Morocco.
Naoual El MenyiyLaboratory of Pharmacology, National Agency of Medicinal and Aromatic Plants, Taounate 34025, Morocco.ORCID 0000-0002-4842-2056
Nasreddine El OmariLaboratory of Histology, Embryology and Cytogenetic, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat 10100, Morocco.ORCID 0000-0002-0308-1155
Hamza AssaggafDepartment of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0001-5563-9491
Learn-Han LeeNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya 47500, Malaysia.ORCID 0000-0002-8589-7456
Domenico MontesanoDepartment of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-8857-2091
Monica GalloDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-6281-426X
Gokhan ZenginDepartment of Biology, Science Faculty, Selcuk University, 42130 Konya, Turkey.ORCID 0000-0001-6548-7823
Yusra AlDhaheriDepartment of Biology, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates.
Abdelhakim BouyahyaLaboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat 10106, Morocco.
Mohammed V University · MAUniversity of Naples Federico II · ITMonash University Malaysia · MYSelçuk University · TRUmm al-Qura University · SAUnited Arab Emirates University · AEUniversité Ibn Zohr · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease remains one of the most widespread neurodegenerative reasons for dementia worldwide and is associated with considerable mortality and morbidity. Therefore, it has been considered a priority for research. Indeed, several risk factors are involved in the complexity of the therapeutic ways of this pathology, including age, traumatic brain injury, genetics, exposure to aluminum, infections, diabetes, vascular diseases, hypertension, dyslipidemia, and obesity. The pathophysiology of Alzheimer's disease is mostly associated with hyperphosphorylated protein in the neuronal cytoplasm and extracellular plaques of the insoluble β-amyloid peptide. Therefore, the management of this pathology needs the screening of drugs targeting different pathological levels, such as acetylcholinesterase (AchE), amyloid

Indexed as

Alzheimer DiseaseNanoparticlesAcetylcholinesteraseAmyloid beta-PeptidesHumansPhytochemicalsAcetylcholinesteraseAmyloid beta-PeptidesPhytochemicalsAlzheimer’s diseasebioactive compoundnano-drugsneuroinflammation

Identifiers

PMID36558176
PMCPMC9781052
OpenAlexW4312196282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.