Evidence map›Paper›PMID 36558052›Full record

ArticleMolecules (Basel, Switzerland)2022

Chemical Analysis and Antimicrobial Activity of

Attilio Anzano, Bruna de Falco, Mohammad Ammar, Annarita Ricciardelli, Laura Grauso, Mohammed Sabbah, Rosanna Capparelli, Virginia Lanzotti

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Recent Advances inBiology · 2026
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  10. Characterization ofPolymers · 2023
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  11. Molecular Docking and ADME-TOX Profiling ofAdvances in respiratory medicine · 2023
    Article
  12. Article
  13. International journal of molecular sciences · 2023
    Review
  14. Phytochemical, antioxidant, and antibacterial activity ofJournal of oral biology and craniofacial research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Attilio AnzanoDipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.
Bruna de FalcoCanarian Science and Technology Park Foundation, Spanish Bank of Algae, University of Las Palmas de Gran Canaria, 35214 Telde, Spain.ORCID 0000-0002-9036-8567
Mohammad AmmarDepartment of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus P.O. Box 7, Palestine.
Annarita RicciardelliDipartimento di Biologia, Università di Napoli Federico II, Complesso di Monte Sant'Angelo-Via Vicinale Cupa Cintia, 21, 80126 Naples, Italy.ORCID 0000-0003-2084-0579
Laura GrausoDipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.ORCID 0000-0001-9165-8796
Mohammed SabbahDepartment of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus P.O. Box 7, Palestine.ORCID 0000-0003-4631-8156
Rosanna CapparelliDipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.
Virginia LanzottiDipartimento di Agraria, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.ORCID 0000-0002-3026-6593
University of Naples Federico II · ITAn-Najah National University · PSUniversidad de Las Palmas de Gran Canaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moringa oleifera is a traditional food crop widespread in Asiatic, African, and South American continents. The plant, able to grow in harsh conditions, shows a high nutritional value and medicinal potential evidencing cardioprotective, anti-inflammatory, antioxidant, and antimicrobial properties. The purpose of this study was the phytochemical analysis of M. oleifera and the identification of the antimicrobial compounds by combining a chemical approach with in vitro tests. The metabolite profile of M. oleifera polar and apolar extracts of leaves and seeds were investigated by using Nuclear Magnetic Resonance spectroscopy and Gas Chromatography-Mass Spectrometry. The antimicrobial activity of all of the obtained extract was evaluated against four bacterial pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and Salmonella enterica). The chemical analysis provided a wide set of metabolites that were identified and quantified. Moreover, apolar extracts from seeds showed a significant concentration-dependent antimicrobial activity against S. aureus and S. epidermidis, (4 mg/mL reduced the viability up to 50%) that was associated to the content of specific fatty acids. Our results remarked the advantages of an integrated approach for the identification of plant metabolites and its use in association with biological tests to recognize the compounds responsible for bioactivity without compounds purification.

Indexed as

Anti-Infective AgentsMoringa oleiferaGas Chromatography-Mass SpectrometryPlant ExtractsPlant LeavesSeedsStaphylococcus aureusAnti-Infective AgentsPlant Extractsbioactive metabolitesGC-MSMoringaceaeMoringa oleiferanatural productsNMRPseudomonas aeruginosaSalmonella entericaStaphylococcus aureusStaphylococcus epidermidis

Identifiers

PMID36558052
PMCPMC9782826
OpenAlexW4311793636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.