Evidence map›Paper›PMID 36557969›Full record

ArticleMolecules (Basel, Switzerland)2022

Docetaxel Loaded in Copaiba Oil-Nanostructured Lipid Carriers as a Promising DDS for Breast Cancer Treatment.

Fabiola Vieira de Carvalho, Ligia Nunes de Morais Ribeiro, Ludmilla David de Moura, Gustavo Henrique Rodrigues da Silva, Hery Mitsutake, Talita Cesarim Mendonça, Gabriela Geronimo, Marcia Cristina Breitkreitz, Eneida de Paula

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  5. Bioavailability for the Improved Therapeutic Profile ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Fabiola Vieira de CarvalhoDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.ORCID 0000-0002-4450-0563
Ligia Nunes de Morais RibeiroDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.ORCID 0000-0001-6097-5449
Ludmilla David de MouraDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.ORCID 0000-0002-8449-5762
Gustavo Henrique Rodrigues da SilvaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.ORCID 0000-0001-7377-8532
Hery MitsutakeDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.ORCID 0000-0002-8769-0301
Talita Cesarim MendonçaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.
Gabriela GeronimoDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.
Marcia Cristina BreitkreitzDepartment of Analytical Chemistry, Institute of Chemistry, UNICAMP, Campinas 13083-970, Brazil.
Eneida de PaulaDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas-UNICAMP, Campinas 13083-862, Brazil.ORCID 0000-0003-4504-5723
Universidade Estadual de Campinas (UNICAMP) · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior F.V.C. scholarshipNational Council for Scientific and Technological Development E.P. fellowshipSão Paulo Research Foundation # 19/17784-0
6 · The paper itself

Abstract

Breast cancer is the neoplasia of highest incidence in women worldwide. Docetaxel (DTX), a taxoid used to treat breast cancer, is a BCS-class-IV compound (low oral bioavailability, solubility and intestinal permeability). Nanotechnological strategies can improve chemotherapy effectiveness by promoting sustained release and reducing systemic toxicity. Nanostructured lipid carriers (NLC) encapsulate hydrophobic drugs in their blend-of-lipids matrix, and imperfections prevent drug expulsion during storage. This work describes the preparation, by design of experiments (2

Indexed as

Antineoplastic AgentsBreast NeoplasmsNanoparticlesNanostructuresOils, VolatileDelayed-Action PreparationsDocetaxelDrug CarriersFemaleHumansParticle SizeAntineoplastic AgentsDelayed-Action PreparationsDocetaxelDrug CarriersOils, Volatilebreast cancerdocetaxelnanostructured lipid carriers

Identifiers

PMID36557969
PMCPMC9788038
OpenAlexW4311389599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.