Evidence map›Paper›PMID 36557936›Full record

ReviewMolecules (Basel, Switzerland)2022

Food Peptides, Gut Microbiota Modulation, and Antihypertensive Effects.

Patrick Blondin Tsafack, Chen Li, Apollinaire Tsopmo

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Patrick Blondin TsafackNutrition and Functional Food, School of Biosciences and Veterinary Medicine, University of Camerino, Via A. D'Accorso, 16, 62032 Camerino, Italy.ORCID 0000-0002-1065-1283
Chen LiSchool of Life Science, Shanxi University, Taiyuan 030006, China.ORCID 0000-0002-0863-9605
Apollinaire TsopmoFood Science and Nutrition Program, Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.ORCID 0000-0002-7062-0833
Carleton University · CAShanxi University · CNUniversità di Camerino · IT

Funding

Natural Sciences and Engineering Research Council 371908
6 · The paper itself

Abstract

The gut microbiota is increasingly important in the overall human health and as such, it is a target in the search of novel strategies for the management of metabolic disorders including blood pressure, and cardiovascular diseases. The link between microbiota and hypertension is complex and this review is intended to provide an overview of the mechanism including the production of postbiotics, mitigation of inflammation, and the integration of food biological molecules within this complex system. The focus is on hydrolyzed food proteins and peptides which are less commonly investigated for prebiotic properties. The analysis of available data showed that food peptides are multifunctional and can prevent gut dysbiosis by positively affecting the production of postbiotics or gut metabolites (short-chain fatty acids, polysaccharides, biogenic amines, bile acids). Peptides and the postbiotics then displayed antihypertensive effects via the renin-angiotensin system, the gut barrier, the endothelium, and reduction in inflammation and oxidative stress. Despite the promising antihypertensive effect of the food peptides via the modulation of the gut, there is a lack of human studies as most of the works have been conducted in animal models.

Indexed as

Antihypertensive AgentsGastrointestinal MicrobiomeAnimalsHumansInflammationPeptidesPrebioticsAntihypertensive AgentsPeptidesPrebioticsfood peptideshypertensioninflammationmicrobiota

Identifiers

PMID36557936
PMCPMC9788432
OpenAlexW4312127996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.