Evidence map›Paper›PMID 36557921›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis and Assay of Novel Methylxanthine-Alkynylmethylamine Derivatives as Acetylcholinesterase Inhibitors.

Danila V Reshetnikov, Igor D Ivanov, Dmitry S Baev, Tatyana V Rybalova, Evgenii S Mozhaitsev, Sergey S Patrushev, Valentin A Vavilin, Tatyana G Tolstikova, Elvira E Shults

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Structural Bioinformatics Applied to Acetylcholinesterase Enzyme Inhibition.International journal of molecular sciences · 2025
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Danila V ReshetnikovN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave, 9, 630090 Novosibirsk, Russia.
Igor D IvanovThe Federal Research Center Institute of Molecular Biology and Biophysics, Timakov Str., 2/12, 630117 Novosibirsk, Russia.
Dmitry S BaevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave, 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-1795-9256
Tatyana V RybalovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave, 9, 630090 Novosibirsk, Russia.ORCID 0000-0003-2398-5271
Evgenii S MozhaitsevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave, 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-5344-9499
Sergey S PatrushevN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave, 9, 630090 Novosibirsk, Russia.ORCID 0000-0003-4932-0091
Valentin A VavilinThe Federal Research Center Institute of Molecular Biology and Biophysics, Timakov Str., 2/12, 630117 Novosibirsk, Russia.
Tatyana G TolstikovaN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave, 9, 630090 Novosibirsk, Russia.
Elvira E ShultsN.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Lavrentyev Ave, 9, 630090 Novosibirsk, Russia.ORCID 0000-0002-0761-9696
Novosibirsk Institute of Organic Chemistry · RUNovosibirsk State University · RUInstitute of Molecular Biology and Biophysics · RU

Funding

Russian Science Foundation 18-13-00361
6 · The paper itself

Abstract

Xanthine derivatives have been a great area of interest for the development of potent bioactive agents. Thirty-eight methylxanthine derivatives as acetylcholinesterase inhibitors (AChE) were designed and synthesized. Suzuki-Miyaura cross-coupling reactions of 8-chlorocaffeine with aryl(hetaryl)boronic acids, the CuAAC reaction of 8-ethynylcaffeine with several azides, and the copper(I) catalyzed one-pot three-component reaction (A

Indexed as

AcetylcholinesteraseCholinesterase InhibitorsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipXanthinesAcetylcholinesteraseCholinesterase InhibitorsmethylxanthineXanthinesA3-coupling reactionsacetylcholinesterase inhibitorcaffeinemethylxanthinesmolecular docking studytheobrominetheophylline

Identifiers

PMID36557921
PMCPMC9788520
OpenAlexW4312210272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.