ReviewMolecules (Basel, Switzerland)2022
Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- The Preparation of Glabridin-Loaded Liposomes and Their Inhibition Effects on Melanogenesis.Molecules (Basel, Switzerland) · 2026Article
- Arbutin-A Hydroquinone Glycoside: Journey from Food Supplement to Cutting-Edge Medicine.Chinese journal of integrative medicine · 2026Review
- Exploring the Health Effects of Phytoestrogens.Metabolites · 2026Review
- Chemical Characteristics and Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2026Article
- IL3RA identified as novel biomarker and therapeutic target for ERClinical proteomics · 2026Article
- Research progress of ferroptosis in obesity and its complications.Journal of physiology and biochemistry · 2026Review
- Profiling arbutin as a potent cholinesterase and GSK-3β inhibitor and evaluating its cytotoxicity in SH-SY5Y cells for Alzheimer's disease therapy.Turkish journal of biology = Turk biyoloji dergisi · 2026Article
- Exploring the Cancer Therapeutic Potential of Traditional Medicinal Plants by Modulating the Apoptotic Pathway.BioMed research international · 2026Review
- The phytochemical arbutin exerts potent anti-Toxoplasma effects through activation of cell-autonomous defense mechanisms while attenuating inflammation.PLoS neglected tropical diseases · 2025Article
- Arbutin as a potential nephroprotective agent: Dose-related effects in renal ischemia-reperfusion injury.Biomolecules & biomedicine · 2025Article
- A Role for the Plastidial GPT2 Translocator in the Modulation of Lignin Biosynthesis.Plant, cell & environment · 2025Article
- Article
- Allelopathy and Identification of Allelochemicals in the Leaves ofPlants (Basel, Switzerland) · 2025Article
- Potential Use of Selected Natural Compounds with Anti-Biofilm Activity.International journal of molecular sciences · 2025Review
- Natural products targeting the MAPK signaling pathway: potential options for ulcerative colitis treatment.Frontiers in pharmacology · 2025Review
- Arbutin's Potential in Neuroprotection: A Promising Role in Mitigating Neurodegenerative Diseases.Current drug research reviews · 2025Review
- Arbutin protects against methotrexate-induced pulmonary injury in rats via modulation of oxidative stress, inflammation, and ER stress.Frontiers in veterinary science · 2025Article
- Effect of the Type of Herbal Preparations (Powdered Plant Material vs. Dry Ethanolic Extracts) on the Bioaccessibility of Bearberry (Molecules (Basel, Switzerland) · 2024Article
- Faecal Metabolome Profiles in Individuals Diagnosed with Hyperplastic Polyps and Conventional Adenomas.International journal of molecular sciences · 2024Article
- Heterocyclic phytometabolites formononetin and arbutin preventToxicology reports · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e.g., antioxidant, antimicrobial and anti-inflammatory, as well as anticancer potential. This review presents, for the first time, a comprehensive overview of the distribution of arbutin in the plant kingdom and critically appraises its therapeutic potential as an anticancer agent based on the literature published until the end of August 2022, accessed via several databases, e.g., Web of Science, Science Direct, Dictionary of Natural Products, PubMed and Google Scholar. The keywords used in the search were arbutin, cancer, anticancer, distribution and hydroquinone. Published outputs suggest that arbutin has potential anticancer properties against bladder, bone, brain, breast, cervix, colon, liver, prostate and skin cancers and a low level of acute or chronic toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.