ArticleMolecules (Basel, Switzerland)2022
Cold Ethanol Extraction of Cannabinoids and Terpenes from Cannabis Using Response Surface Methodology: Optimization and Comparative Study.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Interpol review of forensic drug chemistry, 2022-2025.Forensic science international. Synergy · 2026Review
- Bioactive Compounds and In Vitro Antibacterial Activity of Hemp Leaves and Inflorescences as Potential Functional Feed Ingredients for Canine Nutrition.Animals : an open access journal from MDPI · 2026Article
- The Effect of Wood Chips with Various Degrees of Toasting on the Quality and Sensory Parameters of Fruit Distillates.Molecules (Basel, Switzerland) · 2026Article
- Cannabis flower crude extracts as belowground infochemicals shaping the chemotactic responses of parasitic nematodes.Scientific reports · 2026Article
- Optimization, Kinetics, and Thermodynamics of Ultrasound-Assisted Extraction of Phytochemicals from Hemp.ACS omega · 2025Article
- Assisted Extraction of Hemp Oil and Its Application to Design Functional Gluten-Free Bakery Foods.Molecules (Basel, Switzerland) · 2025Article
- Correlation between Chemical Fertilization Practices, Phytochemical Response, and Biological Activities ofCombinatorial chemistry & high throughput screening · 2025Review
- Challenges of Extracting and Determining Cannabinoids in Different Matrices.Cannabis and cannabinoid research · 2024Review
- Effect of Hemp Extraction Procedures on Cannabinoid and Terpenoid Composition.Plants (Basel, Switzerland) · 2024Article
- Data on terpene content in pre-rolled cone paper infused with terpene-containing flavours based on the formation of a partially soluble precipitate.Data in brief · 2024Article
- Cannabidiol-Loaded Solid Lipid Nanoparticles Ameliorate the Inhibition of Proinflammatory Cytokines and Free Radicals in an In Vitro Inflammation-Induced Cell Model.International journal of molecular sciences · 2024Article
- Mineral nutrition forFrontiers in plant science · 2024Article
- Pilot-Scale Preparation of Broad-Spectrum CBD: Extraction Optimization and Purification using Centrifugal Partition Chromatography.Medical cannabis and cannabinoidsArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Efficient cannabis biomass extraction can increase yield while reducing costs and minimizing waste. Cold ethanol extraction was evaluated to maximize yield and concentrations of cannabinoids and terpenes at different temperatures. Central composite rotatable design was used to optimize two independent factors: sample-to-solvent ratio (1:2.9 to 1:17.1) and extraction time (5.7 min-34.1 min). With response surface methodology, predicted optimal conditions at different extraction temperatures were a cannabis-to-ethanol ratio of 1:15 and a 10 min extraction time. With these conditions, yields (g 100 g dry matter
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Registered trials
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