Evidence map›Paper›PMID 36557912›Full record

ReviewMolecules (Basel, Switzerland)2022

Recent Advances in Natural Polyphenol Research.

Irene Dini, Lucia Grumetto

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Potential Health Benefits of Dietary Antioxidants.Antioxidants (Basel, Switzerland) · 2026
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Phytochemical Analysis and Phytometabolomic Profiling ofInternational journal of molecular sciences · 2025
    Article
  18. Comparative Analysis of Polyphenol-Rich Extracts fromMolecules (Basel, Switzerland) · 2025
    Article
  19. The Antiviral Activity of Polyphenols.Molecular nutrition & food research · 2025
    Review
  20. Protective Potential ofCurrent issues in molecular biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Irene DiniDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy.ORCID 0000-0003-1418-1431
Lucia GrumettoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy.ORCID 0000-0002-3529-1819
University of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyphenols are secondary metabolites produced by plants, which contribute to the plant's defense against abiotic stress conditions (e.g., UV radiation and precipitation), the aggression of herbivores, and plant pathogens. Epidemiological studies suggest that long-term consumption of plant polyphenols protects against cardiovascular disease, cancer, osteoporosis, diabetes, and neurodegenerative diseases. Their structural diversity has fascinated and confronted analytical chemists on how to carry out unambiguous identification, exhaustive recovery from plants and organic waste, and define their nutritional and biological potential. The food, cosmetic, and pharmaceutical industries employ polyphenols from fruits and vegetables to produce additives, additional foods, and supplements. In some cases, nanocarriers have been used to protect polyphenols during food processing, to solve the issues related to low water solubility, to transport them to the site of action, and improve their bioavailability. This review summarizes the structure-bioactivity relationships, processing parameters that impact polyphenol stability and bioavailability, the research progress in nanocarrier delivery, and the most innovative methodologies for the exhaustive recovery of polyphenols from plant and agri-waste materials.

Indexed as

Dietary SupplementsPolyphenolsAntioxidantsFruitPlantsVegetablesAntioxidantsPolyphenolsagri-food wastesantioxidantbioavailabilitycircular economycosmeceuticalsflavonoidsfunctional foodhealthnano-deliverynutraceuticalspolyphenols activitypolyphenols bioavailabilitysustainability

Identifiers

PMID36557912
PMCPMC9787743
OpenAlexW4312126177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.