Evidence map›Paper›PMID 36557905›Full record

ArticleMolecules (Basel, Switzerland)2022

Neuroprotective Properties of Cardoon Leaves Extracts against Neurodevelopmental Deficits in an In Vitro Model of Rett Syndrome Depend on the Extraction Method and Harvest Time.

Mariachiara Spennato, Ottavia Maria Roggero, Simona Varriale, Fioretta Asaro, Angelo Cortesi, Jan Kašpar, Enrico Tongiorgi, Cinzia Pezzella, Lucia Gardossi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mariachiara SpennatoDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.ORCID 0000-0003-0908-1196
Ottavia Maria RoggeroDepartment of Life Sciences, University of Trieste, Via L. Giorgieri 5, 34127 Trieste, Italy.ORCID 0000-0002-7159-5262
Simona VarrialeDepartment of Chemical Sciences, University Federico II of Naples, Via Cinthia, 4, 80126 Napoli, Italy.ORCID 0000-0003-3054-3375
Fioretta AsaroDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.ORCID 0000-0002-8281-8038
Angelo CortesiDepartment of Engineering and Architecture, University of Trieste, Via Alfonso Valerio 6/A, 34127 Trieste, Italy.ORCID 0000-0003-2227-7935
Jan KašparDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.ORCID 0000-0002-1334-7201
Enrico TongiorgiDepartment of Life Sciences, University of Trieste, Via L. Giorgieri 5, 34127 Trieste, Italy.ORCID 0000-0003-0485-0603
Cinzia PezzellaDepartment of Chemical Sciences, University Federico II of Naples, Via Cinthia, 4, 80126 Napoli, Italy.ORCID 0000-0001-5694-472X
Lucia GardossiDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, Via L. Giorgieri 1, 34127 Trieste, Italy.ORCID 0000-0002-8908-2625
University of Trieste · ITUniversity of Naples Federico II · IT

Funding

Ministry of Education, Universities and Research CARDIGAN PROJECTProRett research ONLUS (Italy) PhD (O.R.) fellowship of the University of Trieste co-funded
6 · The paper itself

Abstract

This study investigates the bioactive properties of different extracts of cardoon leaves in rescuing neuronal development arrest in an in vitro model of Rett syndrome (RTT). Samples were obtained from plants harvested at different maturity stages and extracted with two different methodologies, namely Naviglio

Indexed as

CynaraRett SyndromeLactonesLupanesOleanolic AcidPlant ExtractsSesquiterpenesSqualenecynaropicrinLactonesLupaneslupeolOleanolic AcidPlant ExtractsSesquiterpenesSqualenetaraxerolbioactive moleculesbioeconomycardoon leavesNaviglio®plant extractsRett syndromesupercritical carbon dioxide

Identifiers

PMID36557905
PMCPMC9783035
OpenAlexW4312126370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.